Results 161 to 170 of about 378,031 (307)

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Constant scalar curvature hypersurfaces with spherical boundary in Euclidean space

, 2002
It is still an open question whether a compact embedded hypersurface in the Euclidean space with constant mean curvature and spherical boundary is necessarily a hyperplanar ba1l or a spherical cap, even in the simplest case of a compact constant mean ...
Malacarne, J.M., Alías Linares, Luis José   +1 more
core  

Randers Metrics of Constant Scalar Curvature

, 2013
.Randers metrics are a special class of Finsler metrics. Every Randers metric can be expressed in terms of a Riemannian metric and a vector field via Zermelo navigation.
Sevim Esra Sengelen, Sevim, Esra Sengelen, Zhongmin Shen, Shen, Zhongmin   +3 more
core   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

On Curvature Pinching for Submanifolds with Parallel Normalized Mean Curvature Vector

Mathematics
In this note, we investigate the pinching problem for oriented compact submanifolds of dimension n with parallel normalized mean curvature vector in a space form Fn+p(c).
Juanru Gu, Yao Lu
doaj   +1 more source

Normal scalar curvature conjecture

, 2008
O objetivo desta dissertaÃÃo à apresentar uma demonstraÃÃo para uma desigualdade pontual, denominada conjectura da curvatura escalar normal, a qual à vÃlida para subvariedades n-dimensionais, Mn, imersas isometricamente em formas espaciais Nn+m(c) de ...
Aurineide Castro Fonseca
core  

Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus

FEBS Open Bio, EarlyView.
BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima, Gustavo Narvaes Guimarães, Emilyane de Oliveira Santana Amaral, Bianca Caroline Figueiredo Bianco, Manuel Jara‐Espejo, Sérgio Roberto Peres Line, Ana Paula de Souza, Aline Cristiane Planello   +7 more
wiley   +1 more source

Generalized Birecurrent Finsler Geometry: Curvature Identities and Mathematical Foundations for Mechanical and Renewable Energy Systems

Wadi Alshatti University Journal of Pure and Applied Sciences
This paper investigates a class of generalized birecurrent Finsler spaces characterized by a generalized recurrence condition imposed on Cartan’s third curvature tensor with respect to Cartan’s connection.
Wafa'a H. A. Hadi, Adel Mohammed Ali Al-Qashbari, Rahma S. Elzer   +2 more
doaj   +1 more source

Gap phenomenon for scalar curvature [PDF]

Inspired by Goette-Semmelmann \cite{GSSU2002}, we derive an estimate for the scalar curvature without a nonnegativity assumption on curvature operator.
Sun, Yukai, Wang, Changliang
core  

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source