Results 141 to 150 of about 193,587 (326)

Scalar curvature of spheres

open access: yesMathematische Zeitschrift, 1989
The author shows the following result: If \(m\not\equiv 1\) (Mod 4), and \(m\geq 4\), every smooth function of \(S^ m\) is the scalar curvature of some metric of unit total volume.
openaire   +2 more sources

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata   +10 more
wiley   +1 more source

Multiply Warped Products with a Semisymmetric Metric Connection

open access: yesAbstract and Applied Analysis, 2014
We study the Einstein multiply warped products with a semisymmetric metric connection and the multiply warped products with a semisymmetric metric connection with constant scalar curvature, and we apply our results to generalized Robertson-Walker space ...
Yong Wang
doaj   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

open access: yesMolecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy   +10 more
wiley   +1 more source

Hagedorn temperature from the thermal scalar in AdS and pp-wave backgrounds

open access: yesJournal of High Energy Physics
We propose a thermal scalar equation of motion (EOM) that takes into account curvature corrections for backgrounds supported by Ramond-Ramond fluxes.
Troels Harmark
doaj   +1 more source

Colliding scalar pulses in the Einstein-Gauss-Bonnet gravity

open access: yesEPJ Web of Conferences, 2018
We numerically investigated how the nonlinear dynamics depends on the dimensionality and on the higher-order curvature corrections in the form of Gauss-Bonnet (GB) terms, with a model of colliding scalar pulses in plane-symmetric space-time.
Shinkai Hisaaki, Torii Takashi
doaj   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

open access: yesFEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz   +9 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

open access: yesFEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies   +3 more
wiley   +1 more source

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