Results 121 to 130 of about 13,851 (306)

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

On the (α, β)-Metrics of Conformally Flat Type With Weakly Isotropic Scalar Curvature

Journal of Mathematics
This paper considers Matsumoto metrics of conformally flat type that have weakly isotropic scalar curvature and proves that they reduce to Riemannian metrics or locally Minkowski metrics. In this case, they have zero scalar curvature. Similar results are
Mosayeb Zohrehvand
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Complete Yamabe solitons with finite total scalar curvature

, 2019
In this paper, we show that steady or shrinking complete gradient Yamabe solitons with finite total scalar curvature and non-positive Ricci curvature are Ricci flat.
Maeta, Shun, Shun Maeta
core   +1 more source

Thermodynamic geometry of holographic superconductors

Physics Letters B, 2016
We obtain the thermodynamic geometry of a (2+1) dimensional strongly coupled quantum field theory at a finite temperature in a holographic setup, through the gauge/gravity correspondence.
Sayan Basak, Pankaj Chaturvedi, Poulami Nandi, Gautam Sengupta   +3 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

On the role of the parity violating Hojman–Holst term in gravity theories

Physics Letters B
We study Parity Violating Gravity Theories whose gravitational Lagrangian is a generic function of the scalar curvature and the parity odd curvature pseudoscalar, commonly known as the Holst (or Hojmann) term.
Damianos Iosifidis
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Effective Gravitational “Constant” in Scalar-(Curvature)Tensor and Scalar-Torsion Gravities

Universe, 2017
In theories where a scalar field couples nonminimally to gravity, the effective gravitational “constant” becomes dependent on the value of the scalar field.
Laur Järv
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source