Results 131 to 140 of about 378,031 (307)

Negative scalar curvature metrics on noncompact manifolds

open access: yes, 1989
In this paper we prove that every noncompact smooth manifold admits a complete metric of constant negative scalar curvature.
John Bland, Morris Kalka
core   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

open access: yesMolecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David   +12 more
wiley   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

open access: yesMolecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir   +9 more
wiley   +1 more source

A note on the scalar curvature of a compact Riemannian manifold

open access: yesДифференциальная геометрия многообразий фигур
In the present paper, we formulate conditions for the cons­tan­cy of the scalar curvature of an -dimensional compact Rie­mannian manifold . In particular, conditions for the cons­tan­cy of the scalar curvature of in the case of the quasi-ne­ga­tive ...
I. A. Alexandrova, S. E. Stepanov
doaj   +1 more source

A geometric formulation of Higgs Effective Field Theory: Measuring the curvature of scalar field space

open access: yesPhysics Letters B, 2016
A geometric formulation of Higgs Effective Field Theory (HEFT) is presented. Experimental observables are given in terms of geometric invariants of the scalar sigma model sector such as the curvature of the scalar field manifold M.
Rodrigo Alonso   +2 more
doaj   +1 more source

The scalar curvature in formal deformation quantization. I [PDF]

open access: yes, 2022
In the framework of formal deformation quantization, we apply our formal moment map construction on the space of almost complex structures to recover the Donaldson-Fujiki moment map picture of the Hermitian scalar curvature.
La Fuente-Gravy, Laurent
core  

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

open access: yesMolecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Inequality for Ricci curvature of certain submanifolds in locally conformal almost cosymplectic manifolds

open access: yesInternational Journal of Mathematics and Mathematical Sciences, 2005
We establish inequalities between the Ricci curvature and the squared mean curvature, and also between the k-Ricci curvature and the scalar curvature for a slant, semi-slant, and bi-slant submanifold in a locally conformal almost cosymplectic manifold ...
Dae Won Yoon
doaj   +1 more source

Scalar Curvature in Dimension 4 [PDF]

open access: yes
We prove that every locally conformally flat metric on a closed, oriented hyperbolic $4$-manifold with scalar curvature bounded below by $-12$ satisfies Schoen’s conjecture.
Deng, Jialong
core   +1 more source

Attitudes of cancer patients toward ctDNA‐based liquid biopsy for follow‐up

open access: yesMolecular Oncology, EarlyView.
This mixed‐methods study explored cancer patients' experiences, knowledge, and preferences regarding ctDNA‐based liquid biopsy for follow‐up. Awareness of ctDNA was low and recall of previous liquid biopsy was imperfect, yet acceptance was high.
Siddharth Chhajlani   +7 more
wiley   +1 more source

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