Results 111 to 120 of about 13,851 (306)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

Non-negative versus positive scalar curvature [PDF]

open access: yes, 2016
We show that results about spaces or moduli spaces of positive scalar curvature metrics proved using index theory can typically be extended to non-negative scalar curvature metrics.
Wraith, David
core  

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

open access: yesMolecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski   +10 more
wiley   +1 more source

A geometric formulation of Higgs Effective Field Theory: Measuring the curvature of scalar field space

open access: yesPhysics Letters B, 2016
A geometric formulation of Higgs Effective Field Theory (HEFT) is presented. Experimental observables are given in terms of geometric invariants of the scalar sigma model sector such as the curvature of the scalar field manifold M.
Rodrigo Alonso   +2 more
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

open access: yesMolecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht   +3 more
wiley   +1 more source

Inequality for Ricci curvature of certain submanifolds in locally conformal almost cosymplectic manifolds

open access: yesInternational Journal of Mathematics and Mathematical Sciences, 2005
We establish inequalities between the Ricci curvature and the squared mean curvature, and also between the k-Ricci curvature and the scalar curvature for a slant, semi-slant, and bi-slant submanifold in a locally conformal almost cosymplectic manifold ...
Dae Won Yoon
doaj   +1 more source

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