Results 91 to 100 of about 193,587 (326)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Epsilon regularity under scalar curvature and entropy lower bounds and volume upper bounds [PDF]

, 2022
Robin Neumayer
openalex   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

On the moduli space curvature at infinity

Journal of High Energy Physics
We analyse the scalar curvature of the vector multiplet moduli space M X VM $$ {\mathcal{M}}_X^{\textrm{VM}} $$ of type IIA string theory compactified on a Calabi-Yau manifold X.
Fernando Marchesano, Luca Melotti, Lorenzo Paoloni   +2 more
doaj   +1 more source

Asymptotic generalized extended uncertainty principle

European Physical Journal C: Particles and Fields, 2020
We present a formalism which allows for the perturbative derivation of the Extended Uncertainty Principle (EUP) for arbitrary spatial curvature models and observers.
Mariusz P. Da̧browski, Fabian Wagner
doaj   +1 more source

RANDERS METRICS OF SCALAR FLAG CURVATURE [PDF]

Journal of the Australian Mathematical Society, 2009
AbstractWe study an important class of Finsler metrics, namely, Randers metrics. We classify Randers metrics of scalar flag curvature whose S-curvatures are isotropic. This class of Randers metrics contains all projectively flat Randers metrics with isotropic S-curvature and Randers metrics of constant flag curvature.
Cheng, Xinyue, Shen, Zhongmin
openaire   +2 more sources

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Kropina Metrics with Isotropic Scalar Curvature via Navigation Data

Mathematics
Through an interesting physical perspective and a certain contraction of the Ricci curvature tensor in Finsler geometry, Akbar-Zadeh introduced the concept of scalar curvature for the Finsler metric.
Yongling Ma, Xiaoling Zhang, Mengyuan Zhang   +2 more
doaj   +1 more source

O(p + 1) x O(p + 1)-Invariant hypersurfaces with zero scalar curvature in euclidean space

Anais da Academia Brasileira de Ciências, 2000
We use equivariant geometry methods to study and classify zero scalar curvature O(p + 1) x O(p + 1)-invariant hypersurfaces in R2p+2 with p > 1.
JOCELINO SATO
doaj   +1 more source