Results 81 to 90 of about 7,082 (264)
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Mathematische Annalen, 1989 The author studies the question whether a given smooth function K on \(S^ n\) is the scalar curvature of a metric conformal to the standard metric. Not all functions can be realized - obstructions have been found by Kazdan-Warner and Bourguignon-Ezin. The author gives various sufficient conditions, related to work of Escobar and Schoen, for a positive ...
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Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Kinetic scalar curvature extended f(R) gravity
Nuclear Physics B, 2018 In this work we study a modified version of vacuum f(R) gravity with a kinetic term which consists of the first derivatives of the Ricci scalar. We develop the general formalism of this kinetic Ricci modified f(R) gravity and we emphasize on cosmological
S.V. Chervon +4 more
doaj +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
D'Atri spaces and the total scalar curvature of hemispheres, tubes and cylinders. [PDF]
Rev Mat Complut, 2023 Csikós B, Elnashar A, Horváth M.
europepmc +1 more source
Deformations of the scalar curvature
Duke Mathematical Journal, 1975 © 1975. Received March 21, 1975. Revision received June 27, 1975. Partially supported by NSF grants GP-39060 and GP 15735, 42225, the Smithsonian Foundation and the Samuel Beatty Fund of the University of Toronto. We thank J. P. Bourguignon for suggesting substantial improvements in Theorem A, M. Cantor for correcting an error in 3, und Y.
Fischer, Arthur E., Marsden, Jerrold E.
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Molecular Oncology, EarlyView.Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant +11 more
wiley +1 more source
Non-minimal two-loop inflation
Physics Letters B, 2015 We investigate the chaotic inflationary model using the two-loop effective potential of a self-interacting scalar field theory in curved spacetime. We use the potential which contains a non-minimal scalar curvature coupling and a quartic scalar self ...
Tomohiro Inagaki +2 more
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ECG Classification Based on Wasserstein Scalar Curvature. [PDF]
Entropy (Basel), 2022 Sun F, Ni Y, Luo Y, Sun H.
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