Results 81 to 90 of about 13,851 (306)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

On the 2-scalar curvature [PDF]

Journal of Differential Geometry, 2010
International ...
Ge, Yuxin, Lin, Chang-Shou, Wang, Guofang   +2 more
openaire   +3 more sources

Renormalising the field-space geometry

Journal of High Energy Physics
We present a systematic study of one-loop quantum corrections in scalar effective field theories from a geometric viewpoint, emphasizing the role of field-space curvature and its renormalisation.
Patrick Aigner, Luigi Bellafronte, Emanuele Gendy, Dominik Haslehner, Andreas Weiler   +4 more
doaj   +1 more source

Curvature corrections to Starobinsky inflation can explain the ACT results

Physics Letters B
We investigate the impact of curvature corrections to Starobinsky inflation in light of the latest observational results from the Atacama Cosmology Telescope (ACT).
Andrea Addazi, Yermek Aldabergenov, Sergei V. Ketov   +2 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Some Applications of Casorati Curvature for Statistical Submanifolds of Sasakian Statistical Manifolds and Locally Homogeneous, Quasi-Umbilical Hypersurfaces

پژوهش‌های ریاضی, 2021
In this paper, in the first part, the affine geometry is assumed as the main framework. Then we have a spacious explanation of necessary introduction in rather different subjects.
Azam Etemad Dehkordy
doaj  

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Scalar curvature and projective embeddings, II [PDF]

The Quarterly Journal of Mathematics, 2001
The paper uses the technique of finite-dimensional approximation to show that a constant scalr curvature Kahler metric (on a polarised algebraic variety without holomorphic vector fields) minimises the Mabuchi functional.
openaire   +3 more sources

Asymptotic generalized extended uncertainty principle

European Physical Journal C: Particles and Fields, 2020
We present a formalism which allows for the perturbative derivation of the Extended Uncertainty Principle (EUP) for arbitrary spatial curvature models and observers.
Mariusz P. Da̧browski, Fabian Wagner
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source