Results 81 to 90 of about 193,587 (326)

Deformation of the Weighted Scalar Curvature

Symmetry, Integrability and Geometry: Methods and Applications, 2023
Inspired by the work of Fischer-Marsden [Duke Math. J. 42 (1975), 519-547], we study in this paper the deformation of the weighted scalar curvature. By studying the kernel of the formal $L_\phi^2$-adjoint for the linearization of the weighted scalar curvature, we prove several geometric results.
Ho, Pak Tung, Shin, Jinwoo
openaire   +2 more sources

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Entire Scalar Curvature Flow and Hypersurfaces of Constant Scalar Curvature in Minkowski Space [PDF]

Methods and Applications of Analysis, 2009
We prove existence in the Minkowski space of entire spacelike hypersurfaces with constant negative scalar curvature and given set of lightlike directions at infinity; we also construct the entire scalar curvature flow with prescribed set of lightlike directions at infinity, and prove that the flow converges to a spacelike hypersurface with constant ...
openaire   +3 more sources

Stable Hypersurfaces with Constant Scalar Curvature [PDF]

Mathematische Zeitschrift, 1993
It is well known that hypersurfaces with constant mean curvature in Riemannian spaces are solutions to the variational problem of minimizing area for volume-preserving variations. Less known is the fact that hypersurfaces with constant scalar curvature in Riemannian spaces of constant sectional curvature are also solutions to a variational problem ...
Carmo, M. do, Alencar, H., Colares, A.G.
openaire   +2 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Renormalising the field-space geometry

Journal of High Energy Physics
We present a systematic study of one-loop quantum corrections in scalar effective field theories from a geometric viewpoint, emphasizing the role of field-space curvature and its renormalisation.
Patrick Aigner, Luigi Bellafronte, Emanuele Gendy, Dominik Haslehner, Andreas Weiler   +4 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Curvature corrections to Starobinsky inflation can explain the ACT results

Physics Letters B
We investigate the impact of curvature corrections to Starobinsky inflation in light of the latest observational results from the Atacama Cosmology Telescope (ACT).
Andrea Addazi, Yermek Aldabergenov, Sergei V. Ketov   +2 more
doaj   +1 more source

Some Applications of Casorati Curvature for Statistical Submanifolds of Sasakian Statistical Manifolds and Locally Homogeneous, Quasi-Umbilical Hypersurfaces

پژوهش‌های ریاضی, 2021
In this paper, in the first part, the affine geometry is assumed as the main framework. Then we have a spacious explanation of necessary introduction in rather different subjects.
Azam Etemad Dehkordy
doaj