Results 61 to 70 of about 7,082 (264)

Deformation of the scalar curvature and the mean curvature

, 2020
On a compact manifold $M$ with boundary $\partial M$, we study the problem of prescribing the scalar curvature in $M$ and the mean curvature on the boundary $\partial M$ simultaneously. To do this, we introduce the notion of singular metric, which is inspired by the early work of Fischer-Marsden in [18] and Lin-Yuan in [23] for closed manifold. We show
Ho, Pak Tung, Huang, Yen-Chang
openaire   +2 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

On the 2-scalar curvature [PDF]

Journal of Differential Geometry, 2010
International ...
Ge, Yuxin, Lin, Chang-Shou, Wang, Guofang   +2 more
openaire   +3 more sources

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Renormalising the field-space geometry

Journal of High Energy Physics
We present a systematic study of one-loop quantum corrections in scalar effective field theories from a geometric viewpoint, emphasizing the role of field-space curvature and its renormalisation.
Patrick Aigner, Luigi Bellafronte, Emanuele Gendy, Dominik Haslehner, Andreas Weiler   +4 more
doaj   +1 more source

Curvature corrections to Starobinsky inflation can explain the ACT results

Physics Letters B
We investigate the impact of curvature corrections to Starobinsky inflation in light of the latest observational results from the Atacama Cosmology Telescope (ACT).
Andrea Addazi, Yermek Aldabergenov, Sergei V. Ketov   +2 more
doaj   +1 more source

Scalar curvature and projective embeddings, II [PDF]

The Quarterly Journal of Mathematics, 2001
The paper uses the technique of finite-dimensional approximation to show that a constant scalr curvature Kahler metric (on a polarised algebraic variety without holomorphic vector fields) minimises the Mabuchi functional.
openaire   +3 more sources

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Some Applications of Casorati Curvature for Statistical Submanifolds of Sasakian Statistical Manifolds and Locally Homogeneous, Quasi-Umbilical Hypersurfaces

پژوهش‌های ریاضی, 2021
In this paper, in the first part, the affine geometry is assumed as the main framework. Then we have a spacious explanation of necessary introduction in rather different subjects.
Azam Etemad Dehkordy
doaj