Results 171 to 180 of about 292,024 (345)

Scalar curvatures on 𝑆ÂČ [PDF]

open access: bronze, 1987
Wen Xiong Chen, Wei Ding
openalex   +1 more source

Pharmacological effects of osimertinib on a chicken chorioallantoic membrane xenograft model with the EGFR exon‐19‐deleted advanced NSCLC mutation

open access: yesFEBS Open Bio, EarlyView.
Osimertinib reduces angiogenesis and PDL1 expression in in ovo tumors, transforming them into ‘cold tumors’ with lower immune activity. Anatomopathological and transcriptomic analyses highlight its therapeutic impact on tumor biology. This study underscores osimertinib's potential to reshape the tumor microenvironment and provides insights into its ...
David BarthĂ©lĂ©my   +14 more
wiley   +1 more source

On scalar curvature rigidity of Vacuum Static Spaces [PDF]

open access: yesarXiv, 2014
In this paper we extend the local scalar curvature rigidity result in [6] to a small domain on general vacuum static spaces, which confirms the interesting dichotomy of local surjectivity and local rigidity about the scalar curvature in general in the light of the paper [10].
arxiv  

A potential tumor suppressor role of PLK2 in glioblastoma

open access: yesFEBS Open Bio, EarlyView.
PLK2 was consistently downregulated in GBM tissues. Overexpression of PLK2 in GBM cell lines U87MG and U251 reduced their tumorigenic potential and enhanced cell cycle arrest and apoptosis. Suggesting that PLK2 overexpression could potentially be leveraged as a therapeutic strategy to inhibit tumor progression and enhance apoptosis, providing new ...
Xiangping Xia   +5 more
wiley   +1 more source

Identification of inhibitors of the Salmonella FraB deglycase, a drug target

open access: yesFEBS Open Bio, EarlyView.
A high‐throughput screen was used to identify inhibitors of Salmonella FraB, a drug target. Characterization of top hits (identified after an additional counter screen) revealed that some triazolidines, thiadiazolidines, and triazolothiadiazoles are mixed‐type inhibitors of FraB.
Jamison D. Law   +6 more
wiley   +1 more source

Einstein like -para Sasakian manifolds

open access: yesKuwait Journal of Science, 2013
Einstein like  -para Sasakian manifolds are introduced. For an  -para Sasakian manifold to be Einstein like, a necessary and sufficient condition in terms of its curvature tensor is obtained.
SADIK KELES   +3 more
doaj  

Acacetin reduces endoplasmic reticulum stress through the P‐eNOS/PERK signaling pathway to attenuate MGO‐induced vascular endothelial cell dysfunction

open access: yesFEBS Open Bio, EarlyView.
We investigated a potential protective effect of acacetin, a naturally occurring flavonoid, against methylglyoxal (MGO)‐induced endothelial dysfunction in human umbilical vein endothelial cells and its mechanism of action. Acacetin can could inhibit MGO‐induced intracellular calcium ion influx, enhance the expression levels of phosphorylated ...
Zhen Zhang   +7 more
wiley   +1 more source

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