Results 41 to 50 of about 9,405,925 (227)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Memory-Kernel Damping in Wave Propagation from a Variational Reservoir Model: Dispersion, Stability, and Fractional Regimes

Fractal and Fractional
Hereditary damping and fractional attenuation are widely used to model wave propagation in complex media, but the variational and spectral origin of the corresponding nonlocal-in-time operators is often left implicit.
Derik W. Gryczak, Gabriel G. da Rocha, Aloisi Somer, Luiz R. Evangelista, Ervin K. Lenzi   +4 more
doaj   +1 more source

On scalar type spectral operators, infinite differentiable and Gevrey ultradifferentiable C₀‐semigroups [PDF]

International Journal of Mathematics and Mathematical Sciences, 2004
Necessary and sufficient conditions for a scalar type spectral operator in a Banach space to be a generator of an infinite differentiable or a Gevrey ultradifferentiable C0‐semigroup are found, the latter formulated exclusively in terms of the operator′s spectrum.
openaire   +2 more sources

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Nonreversible gauge fields in Fokker-Planck dynamics: Supersymmetric Hamiltonians and learned finite forces

Physical Review Research
We formulate stationary-density-preserving nonreversible perturbations of Fokker-Planck dynamics as gauge fields that deform relaxation spectra while leaving the invariant state fixed.
Masayuki Ohzeki
doaj   +1 more source

A characterization of the generators of analytic C₀‐semigroups in the class of scalar type spectral operators [PDF]

Abstract and Applied Analysis, 2004
In the class of scalar type spectral operators in a complex Banach space, a characterization of the generators of analytic C0‐semigroups in terms of the analytic vectors of the operators is found.
openaire   +3 more sources

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Enriched-nonexpansive Plug-and-Play image restoration

Frontiers in Applied Mathematics and Statistics
Plug-and-Play methods solve imaging inverse problems by inserting a learned denoiser into a proximal splitting algorithm. Their convergence theory presently requires the denoiser, or its residual, to be nonexpansive or firmly nonexpansive, a constraint ...
Mohammad Akram, Umar Ishtiaq, Umar Ishtiaq, Umar Ishtiaq, Khaleel Ahmad, Khaleel Ahmad, Khaleel Ahmad, Ioan-Lucian Popa   +7 more
doaj   +1 more source

An outer membrane vesicle‐associated two‐track model for enterotoxigenic Bacteroides fragilis oncogenesis

Molecular Oncology, EarlyView.
Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi, Sang‐Hyeon Yoo, Ki‐Jong Rhee   +2 more
wiley   +1 more source