Results 51 to 60 of about 9,405,925 (227)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Characterization of operators of positive scalar type [PDF]

, 1999
Let \(X\) be a Banach lattice. Necessary and sufficient conditions for a linear operator \(A:D(A) \to X\), \(D(A)\subseteq X\), to be of positive \(C^0\)-scalar type are given. In addition, the question is discussed which conditions on the Banach lattice
Vieten, Peter
core   +2 more sources

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

On spectral inclusion and mapping theorems for scalar type spectral operators and semigroups

, 2020
We establish spectral inclusion and mapping theorems for scalar type spectral operators, generalizing their counterparts for normal operators. Thereby, we extend a precise weak spectral mapping theorem, known to hold for $C_0$-semigroups of normal operators on complex Hilbert spaces, to the more general case of $C_0$-semigroups of scalar type spectral ...
openaire   +2 more sources

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Semi-universality of conformal higher-derivative and conformal higher-spin fields

Journal of High Energy Physics
In this paper, we study thermal partition functions of free exotic conformal field theories, focusing on conformal higher-derivative and conformal higher-spin fields, in the semi-universal limit |ω i | → 1.
Jyotirmoy Mukherjee, Pabitra Ray
doaj   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Local Spectral Property of 2 x 2 Operator Matrices

, 2019
In this paper we study the local spectral properties of 2 x 2 operator matrices. In particular, we show that every 2 x 2 operator matrix with three scalar entries has the single valued extension property.
고응일
core   +1 more source

Inverse spectral theory for symmetric operators with several gaps: scalar-type Weyl functions

Journal of Functional Analysis, 2005
\textit{M. G. Kreǐn} investigated in [Mat. Sb., N. Ser. 20(62), 431--495 (1947; Zbl 0029.14103)] the spectrum of self-adjoint extensions \(\tilde S\) within a gap \(J\) of a densely defined symmetric operator \(S\) with finite deficiency indices. The result was generalized by \textit{J. F. Brasche, H. Neidhardt} and \textit{J. Weidmann} in [Math.
Albeverio, S., Brasche, J.F., Malamud, M.M., Neidhardt, H.   +3 more
openaire   +1 more source