Results 51 to 60 of about 100,158 (234)
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
On scalar type spectral operators, infinite differentiable and Gevrey ultradifferentiable C0‐semigroups [PDF]
International Journal of Mathematics and Mathematical Sciences, 2004 Necessary and sufficient conditions for a scalar type spectral operator in a Banach space to be a generator of an infinite differentiable or a Gevrey ultradifferentiable C0‐semigroup are found, the latter formulated exclusively in terms of the operator′s spectrum.
openaire +2 more sources
Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs
FEBS Open Bio, EarlyView.Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner +7 more
wiley +1 more source
Quantum fluctuations around low-dimensional topological defects [PDF]
, 2009 In these Lectures a method is described to analyze the effect of quantum fluctuations on topological defect backgrounds up to the one-loop level. The method is based on the spectral heat kernel/zeta function regularization procedure, and it is first ...
Alonso-Izquierdo, A. +4 more
core +1 more source
A characterization of the generators of analytic C0‐semigroups in the class of scalar type spectral operators [PDF]
Abstract and Applied Analysis, 2004 In the class of scalar type spectral operators in a complex Banach space, a characterization of the generators of analytic C0‐semigroups in terms of the analytic vectors of the operators is found.
openaire +3 more sources
FEBS Open Bio, EarlyView.The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley +1 more source
On scalar-type spectral operators and Carleman ultradifferentiable C 0-semigroups [PDF]
Ukrainian Mathematical Journal, 2008 Necessary and sufficient conditions for a scalar-type spectral operator in a Banach space to be a generator of a Carleman ultradifferentiable C 0-semigroup are found. The conditions are formulated exclusively in terms of the spectrum of the operator.
openaire +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
CX3CL1 in Early Detection of Alzheimer's Disease: Plasma Dynamics Across Age and Disease Stages
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Backgrounds Alzheimer's disease (AD) is characterized by amyloid‐beta plaques, tau tangles, and neuroinflammation. C‐X3‐C motif chemokine ligand 1 (CX3CL1, also known as fractalkine), a neuroimmune chemokine implicated in AD pathogenesis, shows inconsistent alterations in plasma/serum across studies.
Ling Wang +6 more
wiley +1 more source
Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett +8 more
wiley +1 more source