Results 131 to 140 of about 504,897 (286)
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Network Entropy and Systemic Risk in Dynamic Banking Systems
Complexity, 2017 We investigate network entropy of dynamic banking systems, where interbank networks analyzed include random networks, small-world networks, and scale-free networks. We find that network entropy is positively correlated with the effect of systemic risk in
Liang He, Shouwei Li
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Topology and congestion invariant in global internet-scale networks
, 2010 PhDInfrastructures like telecommunication systems, power transmission grids and the Internet are complex networks that are vulnerable to catastrophic failure.
Huang, Zhijia
core
Penalized homophily latent space models for directed scale-free networks. [PDF]
PLoS One, 2021 Yang H +4 more
europepmc +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Scale-free information systems networks [PDF]
, 2006 Thesis (S.M.)--Massachusetts Institute of Technology, Engineering Systems Division, 2006.Includes bibliographical references (leaves 77-79).Many real, complex networks have been shown to be scale-free.
Ang, Wee Horng
core
True scale-free networks hidden by finite size effects. [PDF]
Proc Natl Acad Sci U S A, 2021 Serafino M +6 more
europepmc +1 more source
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Robustness Analysis of the Scale-free Networks
, 2014 In this paper, we investigate the connectivity of the scale-free networks and introduce degree variance which describes the numerical distance between degree and the average degree of vertices of the scale-free networks, and the degree variance is looked
Zhang, Zhaojun +3 more
core +1 more source