Results 121 to 130 of about 504,897 (286)

Directed and Non-Directed Scale-Free Networks

open access: yes, 2003
Scale-free networks are networks with a scale-free degree distribution, i.e., where the distribution of the number of links per node is a power-law, p(k) = ck .
Alejandro Fabian Rozenfeld   +4 more
core   +1 more source

Scale-free networks in cell biology [PDF]

open access: yesJournal of Cell Science, 2005
A cell's behavior is a consequence of the complex interactions between its numerous constituents, such as DNA, RNA, proteins and small molecules. Cells use signaling pathways and regulatory mechanisms to coordinate multiple processes, allowing them to respond to and adapt to an ever-changing environment.
openaire   +3 more sources

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

open access: yesMolecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak   +10 more
wiley   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

open access: yesMolecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy   +10 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Effects of degree correlations on the explosive synchronization of scale-free networks

open access: yes, 2015
We study the organization of finite-size, large ensembles of phase oscillators networking via scale-free topologies in the presence of a positive correlation between the oscillators’ natural frequencies and the network’s degrees.
Navas, Adrián   +13 more
core   +1 more source

Beyond scale-free networks: integrating multilayer social networks with molecular clusters in the local spread of COVID-19. [PDF]

open access: yesSci Rep, 2023
Fujimoto K   +13 more
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

Boundary and In-Domain Control for Large-Scale Urban Traffic Networks

open access: yes, 2021
This paper presents a novel approach to design control for traffic on large-scale urban networks by analyzing the structure of one single partial differential equation (PDE).
Tumash, Liudmila   +2 more
core  

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