Results 121 to 130 of about 1,692,270 (273)
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Cascades Tolerance of Scale-Free Networks with Attack Cost
International Journal of Computational Intelligence Systems, 2017 Network robustness against cascades is a major topic in the fields of complex networks. In this paper, we propose an attack-cost-based cascading failure model, where the attack cost of nodes is positively related to its degree.
Chen Hong +4 more
doaj +1 more source
NKCC1: A key regulator of glioblastoma progression
Molecular Oncology, EarlyView.Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen +5 more
wiley +1 more source
Random matrix analysis of complex networks
, 2007 We study complex networks under random matrix theory (RMT) framework. Using nearest-neighbor and next-nearest-neighbor spacing distributions we analyze the eigenvalues of adjacency matrix of various model networks, namely, random, scale-free and small ...
B. Bollobás +9 more
core +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Impact of noise and damage on collective dynamics of scale-free neuronal networks
, 2012 We study the role of scale-free structure and noise in collective dynamics of neuronal networks. For this purpose, we simulate and study analytically a cortical circuit model with stochastic neurons.
Goltsev, A. V. +2 more
core +1 more source
Molecular cancer prevention: Intercepting disease
Molecular Oncology, EarlyView.Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco +2 more
wiley +1 more source
Beyond scale-free networks: integrating multilayer social networks with molecular clusters in the local spread of COVID-19. [PDF]
Sci Rep, 2023 Fujimoto K +13 more
europepmc +1 more source
On the influence of topological characteristics on robustness of complex networks
, 2013 In this paper, we explore the relationship between the topological characteristics of a complex network and its robustness to sustained targeted attacks.
Kasthurirathna, Dharshana +2 more
core +1 more source
Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source