Results 111 to 120 of about 504,897 (286)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

New Cumulative Distributions for Scale-free Networks

, 2016
Exploring the topological structures of networks by mathematical methods is powerful and efficient in researching real networks. There are many successful mathematical methods shown in scale-free networks that are forming branches of mathematics and ...
Wang, Xiaomin, Yao, Bing, Wang, Hongyu, Hongyu Wang, Xu, Jin, Bing Yao, Xiaomin Wang, Jin Xu   +7 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Universal fractal scaling of self-organized networks

, 2010
There is an abundance of literature on complex networks describing a variety of relationships among units in social, biological, and technological systems.
Qawi K. Telesford, Jonathan H. Burdette, Satoru Hayasaka, Paul J. Laurienti, Karen E. Joyce   +4 more
core   +1 more source

Cascades Tolerance of Scale-Free Networks with Attack Cost

International Journal of Computational Intelligence Systems, 2017
Network robustness against cascades is a major topic in the fields of complex networks. In this paper, we propose an attack-cost-based cascading failure model, where the attack cost of nodes is positively related to its degree.
Chen Hong, Nai-Yu Yin, Ning He, Oriol Lordan, Jose Maria Sallan   +4 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Scale-free boundary control of multiple aggregates in large-scale networks

, 2021
International audienceThis paper deals with the problem of controlling aggregated linear outputs of a large-scale network to a constant reference value. A multi-output feedback controller is designed such that no information about state vector or system ...
Nikitin, Denis, Frasca, Paolo, Canudas de Wit, Carlos   +2 more
core  

Generation of uncorrelated random scale-free networks [PDF]

, 2005
Uncorrelated random scale-free networks are useful null models to check the accuracy and the analytical solutions of dynamical processes defined on complex networks.
Boguñá, Marián, Pastor Satorras, Romualdo, Boguña Espinal, Marian, Pastor-Satorras, R. (Romualdo), 1967-, Catanzaro, Michele   +4 more
core   +1 more source

Enhancing traffic capacity of scale free networks by changing queuing strategy

Physics Open
In this paper, we propose a new queuing strategy, which called multi-channel strategy, to improve traffic capacity. The multi-channel strategy is proposed according to the degree of the node.
Lingkang Kong, Jian Liu, Xinjian Chu
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source