Results 51 to 60 of about 340,289 (296)

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1

FEBS Letters, EarlyView.
MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson, Robert Gustafsson Westergren, Ingrid Almlöf, Ann‐Sofie Jemth, Martin Scobie, Ulrika Warpman Berglund, Thomas Helleday, Pål Stenmark   +7 more
wiley   +1 more source

Double-Branch Multi-Scale Contextual Network: A Model for Multi-Scale Street Tree Segmentation in High-Resolution Remote Sensing Images

Sensors
Street trees are of great importance to urban green spaces. Quick and accurate segmentation of street trees from high-resolution remote sensing images is of great significance in urban green space management. However, traditional segmentation methods can
Hongyang Zhang, Shuo Liu
doaj   +1 more source

Exploring lipid diversity and minimalism to define membrane requirements for synthetic cells

FEBS Letters, EarlyView.
Designing the lipid membrane of synthetic cells is a complex task, in which its various roles (among them solute transport, membrane protein support, and self‐replication) should all be integrated. In this review, we report the latest top‐down and bottom‐up advances and discuss compatibility and complexity issues of current engineering approaches ...
Sergiy Gan, Victoria Scarpelli, Marten Exterkate   +2 more
wiley   +1 more source

Mode-Seeking on Hypergraphs for Robust Geometric Model Fitting

, 2015
In this paper, we propose a novel geometric model fitting method, called Mode-Seeking on Hypergraphs (MSH),to deal with multi-structure data even in the presence of severe outliers. The proposed method formulates geometric model fitting as a mode seeking
Suter, David, Wang, Hanzi, Xiao, Guobao, Yan, Yan   +3 more
core   +1 more source

The multidrug and toxin extrusion (MATE) transporter DTX51 antagonizes non‐cell‐autonomous HLS1–AMP1 signaling in a region‐specific manner

FEBS Letters, EarlyView.
The Arabidopsis mutants hls1 hlh1 and amp1 lamp1 exhibit pleiotropic developmental phenotypes. Although the functions of the causative genes remain unclear, they act in the same genetic pathway and are thought to generate non‐cell‐autonomous signals.
Takashi Nobusawa, Makoto Kusaba
wiley   +1 more source

Remote Sensing Image Segmentation Using Vision Mamba and Multi-Scale Multi-Frequency Feature Fusion

Remote Sensing
Rapid advancements in remote sensing (RS) imaging technology have heightened the demand for the precise and efficient interpretation of large-scale, high-resolution RS images. Although segmentation algorithms based on convolutional neural networks (CNNs)
Yice Cao, Chenchen Liu, Zhenhua Wu, Lei Zhang, Lixia Yang   +4 more
doaj   +1 more source

Fast determination of coarse grained cell anisotropy and size in epithelial tissue images using Fourier transform

, 2019
Mechanical strain and stress play a major role in biological processes such as wound healing or morphogenesis. To assess this role quantitatively, fixed or live images of tissues are acquired at a cellular precision in large fields of views.
Delanoë-Ayari, H., Durande, M., Graner, F., Guirao, B., Homan, T., Tlili, S.   +5 more
core   +1 more source

Single cis‐elements in brassinosteroid‐induced upregulated genes are insufficient to recruit both redox states of the BIL1/BZR1 DNA‐binding domain

FEBS Letters, EarlyView.
Phytohormone brassinosteroid‐induced gene regulation by the transcription factor BIL1/BZR1 involves redox‐dependent DNA‐binding alternation and interaction with the transcription factor PIF4. The reduced BIL1/BZR1 dimer binds preferred cis‐elements, while oxidation alters its oligomerization state and disrupts DNA‐binding ability.
Shohei Nosaki, Masae Ohtsuka, Takeshi Nakano, Masaru Tanokura, Takuya Miyakawa   +4 more
wiley   +1 more source

Semantic segmentation of remote sensing images based on dual‐channel attention mechanism

IET Image Processing
Due to the inadequate utilization of data correlation and complementarity in the feature extraction process of multimodal remote sensing images, the paper proposes a deep learning semantic segmentation algorithm based on the Dual Channel Attention ...
Jionghui Jiang, Xi'an Feng, Hui Huang
doaj   +1 more source