Results 151 to 160 of about 10,065,631 (384)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Stigma Scale Adaptation and Validation for Measuring COVID-19 Stigma. [PDF]

Cureus, 2023
Pallavi P, Bakhla AK, Akhouri PK, Kisku RR, Bala R.   +4 more
europepmc   +1 more source

Local methods with adaptivity via scaling

Russian Mathematical Surveys
The rapid development of machine learning and deep learning has introduced increasingly complex optimization challenges that must be addressed. Indeed, training modern, advanced models has become difficult to implement without leveraging multiple computing nodes in a distributed environment.
Saveliy Chezhegov, Sergey Skorik, Nikolas Khachaturov, Danil Shalagin, Aram Avetisyan, Aleksandr Beznosikov, Martin Takác 0001, Yaroslav Kholodov, Alexander V. Gasnikov   +8 more
openaire   +2 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Beş Faktörlü Başarı Hedef Yönelim Ölçeğinin Fen Bilimleri Dersi İçin Türkçe’ye Uyarlanması

Anadolu Üniversitesi Eğitim Fakültesi dergisi
Bu çalışmanın amacı Lüftenegger, Bardach, Bergsmann, Schober ve Spiel (2019) tarafından geliştirilen performans hedefin hem normatif hem de görünürlük özelliğini yaklaşım ve kaçınma çerçevesinde ele alan 5 faktörlü Başarı Hedef Yönelim Ölçeği’ni Fen ...
Murat Akyıldız, Barış Demirdağ, Burak Feyzioğlu   +2 more
doaj   +1 more source

Validation of Hospital Anxiety and Depression Scale in an Indonesian population: a scale adaptation study. [PDF]

Fam Med Community Health, 2023
Tiksnadi BB, Triani N, Fihaya FY, Turu' Allo IJ, Iskandar S, Putri DAE.   +5 more
europepmc   +1 more source

Ecosystem-based adaptation for smallholder farmers in agricultural landscapes in Central America: opportunities and constraints [PDF]

, 2014
It is increasingly recognized that climate change will have a disproportionate impact on smallholder farmers, due to their dependence on agriculture for both livelihoods and food security, their often high levels of poverty, location in remote areas and ...
Alpizar, Francisco, Avelino, Jacques, Bautista Solis, Pavel, Donatti, Camila I., Hannah, Lee, Martinez, Ruth, Rapidel, Bruno, Rodriguez, Carlos, Vignola, Raffaele   +8 more
core  

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

The Turkish Adaptation of the Green Motivation Scale and The Effect of the Green Organizational Climate on Green Motivation

Istanbul Management Journal
Today, where the concept of green gains increasing importance, why organizations want to exhibit green behaviors or what motivates them to act green is an important area of research.
Ali Erbaşı, Serap Kalfaoğlu
doaj   +1 more source

Portuguese version of Bern Illegitimates Task Scale: adaptation and evidence of validity. [PDF]

BMC Psychol, 2023
Neves PC, Andrade C, Paixão R, da Silva JT.   +3 more
europepmc   +1 more source