Results 81 to 90 of about 1,957,056 (283)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Turkish Adaptation of the Technology Integration Self-Efficacy Scale for Mathematics Education

Educational Academic Research
The importance of technology integration in the context of teaching and learning mathematics is growing increasingly, making it a significant necessity to evaluate and measure the self-efficacy of pre-service mathematics teachers regarding technology ...
İsak Çevik, Ömer Sinan Can, Mehmet Fatih Öçal   +2 more
doaj   +1 more source

Uncertainty in climate change impacts on basin-scale freshwater resources – preface to the special issue: the QUEST-GSI methodology and synthesis of results [PDF]

, 2011
This paper presents a preface to this Special Issue on the results of the QUEST-GSI (Global Scale Impacts) project on climate change impacts on catchment-scale water resources.
Arnell, Nigel, Gosling, Simon, Kingston, DG, Osborn, TJ, Taylor, RG, Todd, MC   +5 more
core   +2 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Adaptation of the Professional Moral Courage Scale to Turkish Culture: A Validity and Reliability Study

Uluslararası Türk Eğitim Bilimleri Dergisi
In this study, it was aimed to adapt the "Professional Moral Courage" scale developed by Sekerka et al. (2009) to Turkish culture to assess teachers' Professional Moral Courage levels.
Sami Yollu, Hanifi Yumuşak, Mehmet Korkmaz   +2 more
doaj   +1 more source

The adaptation of psychological scales

Ankara Universitesi Egitim Bilimleri Fakultesi Dergisi, 1968
The exchange of knowledge and information is rapidly progressing and the intercultural interaction is gradually developing in these days. The psychological scales developed for a culture can also be used in different ones. Therefore, it must be answered that how appropriate in another culture the scale is?, how strong the psychometrics of scale ...
openaire   +4 more sources

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Psychometric validation of the Turkish Brief General AI Self-Efficacy Scale: examining its role in AI anxiety, acceptance, and demographic predictors

Frontiers in Psychology
BackgroundThe rapid integration of artificial intelligence (AI) technologies in education highlights the urgency of understanding pre-service teachers’ readiness to adopt these tools effectively.
Sedef Çelik Demirci, Metin Besalti, Metin Besalti, Ümit Kul   +3 more
doaj   +1 more source