Results 121 to 130 of about 2,021,170 (319)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

GRAISEA: Mid-Term Evaluation April 2015-September 2016

, 2016
The Gender Transformative & Responsible Business Investment in South East Asia (GRAISEA) programme believes that equitable, sustainable and viable value chains can be built for agriculture commodities through multi-stakeholder cooperation ...

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Evaluation of 'Stories of Change' Goat and Irrigation Projects in Malawi [PDF]

, 2009
Part of the 2009 'Stories of Change' initiative to document and promote Oxfam's programme results more effectively, this evaluation focuses on Oxfam's livelihood rehabilitation programme in Malawi.

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Investigation of Scale Development Studies Conducted in Educational Sciences Published in Turkey by Many-Faceted Rasch Model

, 2017
The aim of this study is to investigate the scale development studies that were conducted in Turkey from 2010 to 2015 and published in the journals indexed in Social Sciences Citation Index (SSCI) by means of their verifications about scale development ...
Gülşen Taşadelen Teker, Kaya Uyanık, Gülden, Gülden Kaya Uyanık, Güler, Neşe, Demir, Süleyman, Neşe Güler, Süleyman Demir, KAYA UYANIK, GÜLDEN, Taşdelen Teker, Gülşen   +8 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Research status quo of quality of life scale for patients with gout

Huli yanjiu, 2016
It introduced quality of life scale for patients with gout,including the general scale and the specific scale.The general scale mainly reflected the health state of the total life quality of patients with gout,but the specificity was not enough;although ...
柳旭, 刘琼玲, 万崇华, 潘海燕, 谢小华   +4 more
doaj  

Measuring the age-friendliness of cities in the Russian Federation: The translation, validation and application of the age-friendly cities and communities Questionnaire in the city of Kazan

Heliyon
Numerous cities in the Russian Federation have joined the World Health Organization's (WHO) Global Network for Age-Friendly Cities and Communities since 2011.
Liliya E. Ziganshina, Aizyara F. Garaeva, Liliya I. Talipova, Rustem N. Khairullin, Jeroen Dikken, Joost van Hoof   +5 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Women's Empowerment in Indonesia: Evaluation of Papua women's empowerment [PDF]

, 2015
This evaluation is presented as part of the Effectiveness Review Series 2013/14, selected for review under the women's empowerment thematic area. This report documents the findings of a quasi-experimental evaluation carried out in October 2013 that ...
Lombardini, Simone, Caeyers, Bet
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