Results 131 to 140 of about 2,021,170 (319)

SENSITIVITY EVALUATION OF THE ELECTRONIC CAR SCALE [PDF]

Scientific Journal of Silesian University of Technology. Series Transport, 2014
During every day activities related with performed work or homework duties we meet a lot of equipment and we don't realize about their complex construction.
Tomasz KĄDZIOŁKA, Sławomir KOWALSKI
doaj  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Social personalized adaptive e-learning environment : Topolor - implementation and evaluation [PDF]

This paper presents a quantitative study on the use of Topolor - a prototype that introduces Web 2.0 tools and Facebook-like appearance into an adaptive educational hypermedia system.
Al Qudah, Dana, Stepanyan, Karen, Shi, Lei, Gkotsis, George, Cristea, Alexandra I.   +4 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

The Garden of Evaluation Approaches Visualization

Background: The Garden of Evaluation Approaches (Montrosse-Moorhead, et al., 2024a) maps evaluation approaches against eight dimensions of practice and situates them in their philosophical orientations and methodological dispositions. Purpose: The Garden’
Becho, Lyssa Wilson, Schröter, Daniela, Montrosse-Moorhead, Bianca   +2 more
core   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Goal Attainment Scale and Clinical Efficacy Evaluation of Acupuncture

康复学报, 2015
Objective:To analyze the application prospect of goal attainment scale (GAS) in clinical efficacy evaluation of acupuncture, and then explore the establishment of individualized clinical assessment system of acupuncture.Methods:This article introduced a ...
Dong LIN, Wanyu ZHUANG, Xiaozhen HUANG, Lili LIN, Qiang WU   +4 more
doaj  

The Psychological Emptiness Scale: a psychometric evaluation

BJPsych Open
Background Feelings of emptiness are commonly reported as deeply distressing experiences. Despite established relationships between emptiness and many mental health difficulties, alongside self-harm and suicide, further study into this phenomenon has ...
Shona Joyce Herron, Rob Saunders, Fabio Sani, Janet Feigenbaum   +3 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source