Results 91 to 100 of about 807,423 (305)

Flexible Rasch Mixture Models with Package psychomix [PDF]

open access: yes
Measurement invariance is an important assumption in the Rasch model and mixture models constitute a flexible way of checking for a violation of this assumption by detecting unobserved heterogeneity in item response data.
Carolin Strobl   +3 more
core  

Inference in two-piece location-scale models with Jeffreys priors [PDF]

open access: yes, 2011
This paper addresses the use of Jeffreys priors in the context of univariate threeparameter location-scale models, where skewness is introduced by differing scale parameters either side of the location.
Rubio, Francisco J., Steel, Mark F. J.
core  

Bayesian mixture labeling and clustering

open access: yes, 2012
Label switching is one of the fundamental issues for Bayesian mixture modeling. It occurs due to the nonidentifiability of the components under symmetric priors. Without solving the label switching, the ergodic averages of component specific quantities
Yao, Weixin
core   +1 more source

Analyzing 2D gel images using a two-component empirical bayes model

open access: yesBMC Bioinformatics, 2011
Background Two-dimensional polyacrylomide gel electrophoresis (2D gel, 2D PAGE, 2-DE) is a powerful tool for analyzing the proteome of a organism. Differential analysis of 2D gel images aims at finding proteins that change under different conditions ...
Li Feng   +1 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

Ultra‐High‐Throughput Nanoliter‐Scale Liquid‐Liquid Extractions and Reaction Mixture Purification

open access: yesAdvanced Materials Interfaces
Miniaturizing chemical processes to the nanoliter scale is essential for reducing costs, increasing throughput, and enabling massively parallel experimentation with tens of thousands of samples.
Michelle J. Iwohn   +2 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

open access: yesMolecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos   +6 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

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