Results 51 to 60 of about 2,056,468 (266)

Comparison of the classification ratios of four depression rating scales commonly used in Turkey

open access: yesPsychiatry and Clinical Psychopharmacology, 2017
Objective: According to literature more than 20 depression scales are in use in Turkey. Considering that depression is a popular area of study, it may not seem abnormally unusual that there are so many measuring scales available.
Gaye Saltukoğlu, Arkun Tatar
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

open access: yesFEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace   +6 more
wiley   +1 more source

C-Reactive Protein, International Normalized Ratio, and Fibrinogen in Diagnostic Scale of Complicated Acute Appendicitis

open access: yesClinics and Practice
Background/Objectives: Differentiating complicated acute appendicitis (CA) and uncomplicated acute appendicitis (UC) is essential to guide clinical management.
Leticia Lorena Hernández-González   +8 more
doaj   +1 more source

Study The Role of Glasgow coma Scale, Neutrophil-Lymphocyte ratio, Platelet-Lymphocyte ratio, and Serum Creatinine as predictors of severity and mortality in acute organophosphorus poisoning [PDF]

open access: yesAin Shams Journal of Forensic Medicine and Clinical Toxicology
Background: Organophosphorus compounds (OPCs) are extremely toxic to humans. Aim: To evaluate the role of the Glasgow Coma Scale, Neutrophil-Lymphocyte ratio (NLR), Platelet-Lymphocyte ratio (PLR), and serum creatinine as predictors of severity and ...
Ghidaa Mohamed   +3 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Discovering Genetic Interactions in Large-Scale Association Studies by Stage-wise Likelihood Ratio Tests.

open access: yesPLoS Genetics, 2015
Despite the success of genome-wide association studies in medical genetics, the underlying genetics of many complex diseases remains enigmatic. One plausible reason for this could be the failure to account for the presence of genetic interactions in ...
Mattias Frånberg   +5 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

open access: yesFEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

Impact of nutrient deficiency and harvesting strategy on biomass and phycocyanin production in Spirulina cultures

open access: yesFrontiers in Bioengineering and Biotechnology
Recent research has focused on issues related to contamination, nutrient availability, and strain selection, but there has been insufficient focus on harvesting research.
Hooi Ren Lim   +3 more
doaj   +1 more source

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