Results 61 to 70 of about 5,116,539 (328)

The Flatness of the Mass-to-Light Ratio on Large Scales [PDF]

open access: yesThe Astrophysical Journal, 1999
AAS Latex file, 8 pages+ 4 figures, accepted for publication in ...
Wen Xu, Li-Zhi Fang
openaire   +3 more sources

Purification tags markedly affect self‐aggregation of CPEB3

open access: yesFEBS Letters, EarlyView.
Although recombinant proteins are used to study protein aggregation in vitro, uncleaved tags can interfere with accurate interpretation. Our findings demonstrate that His₆‐GFP and His₁₂ tags significantly affect liquid droplet and amyloid fibril formation in the intrinsically disordered region (IDR) of mouse cytoplasmic polyadenylation element‐binding ...
Harunobu Saito   +6 more
wiley   +1 more source

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

open access: yesFEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao   +7 more
wiley   +1 more source

Single‐cell insights into the role of T cells in B‐cell malignancies

open access: yesFEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source

b-tau Yukawa (Non-)Unification in the CMSSM

open access: yes, 2011
Supersymmetric Grand Unification usually provides unification of the bottom quark and the tau lepton Yukawa couplings at the GUT scale. In the CMSSM this can be realised only for a very particular choice of parameters.
Monaco, Maurizio, Spinrath, Martin
core   +1 more source

Intron‐oriented HTLV‐1 integration in an adult T‐cell leukemia/lymphoma cell line sustains expression of intact ift81 mRNA

open access: yesFEBS Letters, EarlyView.
In the adult T‐cell leukemia/lymphoma (ATL) cell line ED, the human T‐cell leukemia virus type 1 (HTLV‐1) provirus was integrated into the intron of the ift81 gene in the antisense orientation. Despite this integration, both the intact ift81 and the viral oncogene hbz were simultaneously expressed, likely due to the functional insufficiency of viral ...
Mayuko Yagi   +5 more
wiley   +1 more source

Comparison of the classification ratios of four depression rating scales commonly used in Turkey

open access: yesPsychiatry and Clinical Psychopharmacology, 2017
Objective: According to literature more than 20 depression scales are in use in Turkey. Considering that depression is a popular area of study, it may not seem abnormally unusual that there are so many measuring scales available.
Gaye Saltukoğlu, Arkun Tatar
doaj   +1 more source

A First Look at the Performance of Nano-Grooved Heat Pipes

open access: yes, 2018
Passive thermal spreaders utilizing liquid/vapor phase-change mechanism such as heat pipes, have been widely used in the macro-scale thermal management of electronic devices for many years. Micro-fabrication techniques enabled the fabrication micro-scale
Akkus, Yigit   +3 more
core   +1 more source

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

open access: yesFEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu   +17 more
wiley   +1 more source

Spotlight on the Disc-Damage Likelihood Scale (DDLS)

open access: yesClinical Ophthalmology, 2021
Kelvin KW Cheng, Andrew J Tatham Princess Alexandra Eye Pavilion, Edinburgh, UKCorrespondence: Andrew J TathamPrincess Alexandra Eye Pavilion, Edinburgh, UKTel +44 131 536 3753Email andrewjtatham@gmail.comAbstract: The disc damage likelihood scale (DDLS)
Cheng KKW, Tatham AJ
doaj  

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