Results 61 to 70 of about 5,388,952 (345)

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

open access: yesFEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani   +4 more
wiley   +1 more source

Comparison of the classification ratios of four depression rating scales commonly used in Turkey

open access: yesPsychiatry and Clinical Psychopharmacology, 2017
Objective: According to literature more than 20 depression scales are in use in Turkey. Considering that depression is a popular area of study, it may not seem abnormally unusual that there are so many measuring scales available.
Gaye Saltukoğlu, Arkun Tatar
doaj   +1 more source

The Neutrophil-to-Lymphocyte and Monocyte-to-Lymphocyte Ratios Are Independently Associated With the Severity of Autoimmune Encephalitis

open access: yesFrontiers in Immunology, 2022
BackgroundThe neutrophil-to-lymphocyte ratio (NLR) and monocyte-to-lymphocyte ratio (MLR) are biomarkers that may reflect inflammatory status in some immune-related diseases. This study aims to investigate the association of NLR and MLR with the severity
Zhiwei Liu   +5 more
doaj   +1 more source

A First Look at the Performance of Nano-Grooved Heat Pipes

open access: yes, 2018
Passive thermal spreaders utilizing liquid/vapor phase-change mechanism such as heat pipes, have been widely used in the macro-scale thermal management of electronic devices for many years. Micro-fabrication techniques enabled the fabrication micro-scale
Akkus, Yigit   +3 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Spotlight on the Disc-Damage Likelihood Scale (DDLS)

open access: yesClinical Ophthalmology, 2021
Kelvin KW Cheng, Andrew J Tatham Princess Alexandra Eye Pavilion, Edinburgh, UKCorrespondence: Andrew J TathamPrincess Alexandra Eye Pavilion, Edinburgh, UKTel +44 131 536 3753Email andrewjtatham@gmail.comAbstract: The disc damage likelihood scale (DDLS)
Cheng KKW, Tatham AJ
doaj  

Time after time – circadian clocks through the lens of oscillator theory

open access: yesFEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo   +2 more
wiley   +1 more source

Customized Nutrient Standards to Diagnose Nutrient Imbalance in Fertigated ‘Nanica’ Banana Groves

open access: yesHorticulturae
Banana (Musa spp.) is an important fruit production in Brazil, but crop productivity is still too low. The ‘Nanica’ cultivar and fertigation have been introduced, but more accurate guidelines are needed to support fertilization decisions at the orchard ...
Antonio João de Lima Neto   +6 more
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

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