Results 71 to 80 of about 5,116,539 (328)

Traffic management for large-scale evacuation with public transportation and calculation of appropriate operating ratio

Nuclear Engineering and Technology, 2022
In 2013, the International Atomic Energy Agency (IAEA) changed the recommended maximum range of the Emergency Planning Zone (EPZ) to 30 km, and the Kori Nuclear Power Plant in Republic of Korea has also expanded the EPZ to 30 km, following the ...
Seunghee Ham, Jun Lee, Sang Jo Lee
doaj   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1

FEBS Letters, EarlyView.
MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson, Robert Gustafsson Westergren, Ingrid Almlöf, Ann‐Sofie Jemth, Martin Scobie, Ulrika Warpman Berglund, Thomas Helleday, Pål Stenmark   +7 more
wiley   +1 more source

Disrupting the one-loop renormalization group invariant M/alpha in supersymmetry

, 1998
It is well known that in low energy supersymmetry the ratio of the gaugino mass to the gauge coupling squared, M/alpha, is renormalization group invariant to one-loop.
Alvarez-Gaume, Ambrosanio, Ambrosanio, Ambrosanio, Ambrosanio, Ambrosanio, Arkani-Hamed, Avdeev, Babu, Bagger, Barger, Barger, Binétruy, Brignole, Capper, Carena, Carena, Carone, Castaño, Chankowski, Cheng, Cohen, Cohen, Cremmer, Cvetič, Dasgupta, Davies, de Carlos, del Aguila, del Aguila, del Aguila, del Aguila, Dienes, Dienes, Dimopoulos, Dimopoulos, Dine, Dine, Dine, Drees, Drees, Dvali, Ellis, Ellis, Ellis, Farrar, Feng, Ferreira, Font, Ghilencea, Ghilencea, Graham D. Kribs, Haber, Hall, Hall, Hewett, Hikasa, Hikasa, Hill, Hisano, Hisano, Hisano, Holdom, Ibáñez, Ibáñez, Ibáñez, Ibáñez, Ibáñez, Inoue, Inoue, Jack, Jack, Jack, Kane, Kane, Kaplunovsky, Kawamura, Keith, King, Kolda, Langacker, Lopez, Martin, Martin, Martin, Martin, Mohapatra, Mohapatra, Nelson, Nilles, Nojiri, Nojiri, Novikov, Novikov, Novikov, Olechowski, Pierce, Pierce, Poppitz, Randall, Ring, Ross, Shafi, Shifman, Siegel, Yamada, Yamada, Yamada, Zhang, Zichichi   +109 more
core   +1 more source

Structures in the cosmic ray energy spectra [PDF]

, 2013
All the components of cosmic rays have 'structure' in their energy spectra at some level, ie deviations from a simple power law, and their examination is relevant to the origin of the particles.
Erlykin, Anatoly, Wolfendale, Arnold
core   +1 more source

Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation

FEBS Letters, EarlyView.
The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen, Zenon Toprakcioglu, Michele Vendruscolo   +2 more
wiley   +1 more source

CDSKNNXMBD: a novel clustering framework for large-scale single-cell data based on a stable graph structure

Journal of Translational Medicine
Background Accurate and efficient cell grouping is essential for analyzing single-cell transcriptome sequencing (scRNA-seq) data. However, the existing clustering techniques often struggle to provide timely and accurate cell type groupings when dealing ...
Jun Ren, Xuejing Lyu, Jintao Guo, Xiaodong Shi, Ying Zhou, Qiyuan Li   +5 more
doaj   +1 more source

Correcting batch effects in large-scale multiomics studies using a reference-material-based ratio method

Genome Biology, 2023
Background Batch effects are notoriously common technical variations in multiomics data and may result in misleading outcomes if uncorrected or over-corrected.
Ying Yu, Naixin Zhang, Yuanbang Mai, Luyao Ren, Qiaochu Chen, Zehui Cao, Qingwang Chen, Yaqing Liu, Wanwan Hou, Jingcheng Yang, Huixiao Hong, Joshua Xu, Weida Tong, Lianhua Dong, Leming Shi, Xiang Fang, Yuanting Zheng   +16 more
doaj   +1 more source

Redox‐dependent binding and conformational equilibria govern the fluorescence decay of NAD(P)H in living cells

FEBS Letters, EarlyView.
In this work, we reveal how different enzyme binding configurations influence the fluorescence decay of NAD(P)H in live cells using time‐resolved anisotropy imaging and fluorescence lifetime imaging microscopy (FLIM). Mathematical modelling shows that the redox states of the NAD and NADP pools govern these configurations, shaping their fluorescence ...
Thomas S. Blacker, Nimit Mistry, Nicoletta Plotegher, Elizabeth R. Westbrook, Michael D. E. Sewell, John Carroll, Gyorgy Szabadkai, Angus J. Bain, Michael R. Duchen   +8 more
wiley   +1 more source

C-Reactive Protein, International Normalized Ratio, and Fibrinogen in Diagnostic Scale of Complicated Acute Appendicitis

Clinics and Practice
Background/Objectives: Differentiating complicated acute appendicitis (CA) and uncomplicated acute appendicitis (UC) is essential to guide clinical management.
Leticia Lorena Hernández-González, Said José Serrano-Guzmán, Jesús David Guzmán-Ortiz, Hermelo Esteban Pérez-Ceballos, José Luis Cano-Pérez, Víctor Cruz-Hernández, Héctor Ulises Bernardino-Hernández, Lucía Lourdes Martínez-Martínez, Sergio Roberto Aguilar-Ruiz   +8 more
doaj   +1 more source