Results 51 to 60 of about 984,019 (267)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Scale invariant Einstein-Cartan gravity and flat space conformal symmetry

Journal of High Energy Physics, 2023
We find the conditions under which scale-invariant Einstein-Cartan gravity with scalar matter fields leads to an approximate conformal invariance of the flat space particle theory up to energies of the order of the Planck mass.
Georgios K. Karananas, Mikhail Shaposhnikov, Sebastian Zell   +2 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

A high-resolution lithospheric magnetic field model of China and surroundings by using CHAMP, Swarm, CSES-1, and MSS-1 satellite magnetic measurements and aeromagnetic anomaly data

Earth and Planetary Physics
The CUG_CLMFM3D series comprises high-resolution three-dimensional lithospheric magnetic field models for China and its surroundings. The first version, CUG_CLMFM3Dv1, is a spherical cap harmonic model integrating the WDMAMv2 (World Digital Magnetic ...
Pan Zhang, JinSong Du, Liang Yin, Qing Yan, JiaXuan Zhang, HouPu Li, Keke Zhang, Chao Chen   +7 more
doaj   +1 more source

Computing an Exact Gaussian Scale-Space

Image Processing On Line, 2016
Gaussian convolution is one of the most important algorithms in image processing. The present work focuses on the computation of the Gaussian scale-space, a family of increasingly blurred images, responsible, among other things, for the scale-invariance ...
Ives Rey Otero, Mauricio Delbracio
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

A cubed-sphere based method for global and regional modeling of the lithospheric magnetic field

Earth and Planetary Physics
The Earth’s magnetic field, which has been extensively observed from ground to satellite altitudes over several decades, originates from multiple sources, such as the core dynamo, the conductive mantle, the magnetized lithosphere, and the space current ...
Liang Yin, JiaXuan Zhang, PengFei Liu, HongBo Yao, Pan Zhang, JinSong Du   +5 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

An alternative regularization approach for modeling the regional lithospheric magnetic field from satellite magnetic measurements by the spherical equivalent source method and its application in Africa

Earth and Planetary Physics
The equivalent source (ES) method in the spherical coordinate system has been widely applied to processing, reduction, field modeling, and geophysical and geological interpretation of satellite magnetic anomaly data.
JiangSong Gui, JinSong Du, Pan Zhang, ChangQing Yuan, YuKun Li, KangAn Zhao, Liang Yin, HouPu Li   +7 more
doaj   +1 more source

La question des échelles en géohistoire. Les bureaux de la poste aux lettres du XVIIIe siècle à nos jours

Cybergeo, 2018
Starting from a practice of research that has been going back for years on the question of the use of scales in geohistorical works, this text offers a reflection on the plays of scale, as well as on the question of the MAUP (modifiable areal unit ...
Nicolas Verdier, Ludovic Chalonge
doaj   +1 more source