Results 61 to 70 of about 984,019 (267)

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Revised global vertically integrated remanent magnetization model of the oceanic lithosphere with comparison to LCS-1 model and MSS-1 magnetic measurements

Earth and Planetary Physics
The lithospheric magnetic field is an important component of the geomagnetic field, and the oceanic lithosphere exhibits distinct characteristics. Because of its formation mechanisms, evolutionary history, and geomagnetic field polarity reversals, the ...
ShiDa Sun, Hui Li, JinSong Du, Pan Zhang, Chao Chen, PengFei Liu   +5 more
doaj   +1 more source

Coseismic Rupture Geometry and Slip Rupture Process During the 2018 Mw 7.1 Anchorage, South‐Central Alaska Earthquake: Intraplate Normal Faulting by Slab Tear Constrained by Geodetic and Teleseismic Data

Earth and Space Science, 2020
The Mw 7.1 Anchorage earthquake on 30 November 2018 beneath the south‐central Alaska is a rare intermediate‐depth event larger than Mw 7 that occurred in a complex subduction region, where the young Yakutat oceanic terrane wedges in the continental ...
Ping He, Yangmao Wen, Yunguo Chen, Caijun Xu, Kaihua Ding   +4 more
doaj   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Spatio-Featural Scale-Space

, 2009
Linear scale-space theory is the fundamental building block for many approaches to image processing like pyramids or scale-selection. However, linear smoothing does not preserve image structures very well and thus non-linear techniques are mostly applied for image enhancement.
openaire   +3 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Land Quality, Development and Space: Does Scale Matter?

European Spatial Research and Policy, 2013
This study analyzes empirically the relationship between land quality decline and the spatial distribution of per capita income observed in Italy at different spatial scales and geographical divisions.
Luca Salvati
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Shape recognition using orientational and morphological scale‐spaces of curvatures

IET Computer Vision, 2015
In this study, a scale‐invariant representation for closed planar curves (silhouettes) is proposed. The orientations of all points within the Gaussian scale‐space of the curve are extracted.
Erdem Akagündüz
doaj   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source