Results 161 to 170 of about 3,018,546 (285)

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Adult Hope Scale: validation in older adults. [PDF]

Aust J Psychol
Labrosciano K, Dorrian J, Lowies B, Russell R, Lushington K.   +4 more
europepmc   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

The German translation of the Oxford utilitarianism scale: Validation and the impact of the Covid-19 pandemic on the observations. [PDF]

PLoS One
Ambrasė A, Hendrickx M, Grahlow M, Wong HY, Derntl B.   +4 more
europepmc   +1 more source

Opioid use disorder in two samples of the Lebanese population: scale validation and correlation with sleep and mood disorders. [PDF]

BMC Psychiatry, 2023
Chamoun K, Mouawad J, Salameh P, Sacre H, Haddad R, Khabbaz LR, Megarbane B, Hajj A.   +7 more
europepmc   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Development and Validation of an Owner-Assessed Feline Acute Pain Scale: Validation and Agreement with Veterinary Scales. [PDF]

Animals (Basel)
Rojsiripornchai S, Niyom S, Koatsang N, Kathatip S, Thunpattranon T, Bunjerdsuwan W, Jaroensong T, Kasemsuwan S.   +7 more
europepmc   +1 more source

Large-scale validation study of an improved semiautonomous urine cytology assessment tool: AutoParis-X. [PDF]

Cancer Cytopathol, 2023
Levy JJ, Chan N, Marotti JD, Kerr DA, Gutmann EJ, Glass RE, Dodge CP, Suriawinata AA, Christensen BC, Liu X, Vaickus LJ.   +10 more
europepmc   +1 more source

Happiness at work: measurement scale validation

, 2019
Workers’ happiness is a determining factor of their short- and long-term efficiency. Several scholars have attempted to develop happiness measurement frameworks. The present work analyzes the validity of a scale proposed by Del Junco, Espasandín, Dutschke, and Palacios (2013) in which factors determining worker happiness are elucidated and examined ...
Ramirez-Garcia, Carolina, de Perea, Juan García-Álvarez, Garcia-Del Junco, Julio   +2 more
openaire   +2 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source