Results 31 to 40 of about 2,196,235 (269)

Implementing Measurement-Based Care for Depression: Practical Solutions for Psychiatrists and Primary Care Physicians

open access: yesNeuropsychiatric Disease and Treatment, 2021
Ran Ha Hong,1 Jill K Murphy,1 Erin E Michalak,1 Trisha Chakrabarty,1 Zuowei Wang,2 Sagar V Parikh,3 Larry Culpepper,4 Lakshmi N Yatham,1 Raymond W Lam,1,* Jun Chen5,* 1Department of Psychiatry, University of British Columbia, Vancouver, Canada; 2Hongkou ...
Hong RH   +9 more
doaj  

The Study of a Monumental Structure Ruins to the Southwest of the Cathedral Mosque in Bolgar City

open access: yesПоволжская археология, 2012
The ruins of a large brick building were revealed on the Bolgar city site to the southwest of the Cathedral mosque. The structure was studied during the 1989-1993, 2000 and 2011 excavations. It has been found that that its outer walls were built of baked
Baranov Vyacheslav S.   +2 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

open access: yesFEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi   +5 more
wiley   +1 more source

Impacts of human activity on reindeer and caribou: The matter

open access: yesRangifer, 2007
The impacts of human activity and infrastructure development on reindeer and caribou (Rangifer tarandus) have been studied for decades and have resulted in numerous debates among scientists, developers and indigenous people affected.
Ingunn Vistnes, Christian Nellemann
doaj   +1 more source

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

open access: yesFEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

open access: yesFEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

The effect of subjective fish scale ageing on growth and recruitment analyses: a case study from the UK [PDF]

open access: yesActa Ichthyologica et Piscatoria, 2006
Background. Re-ageing of scales sampled in 1985 from the population of roach, Rutilus rutilus (L.), of the River Stour, England, revealed a high degree of subjectivity in their ageing, resulting from contrasting interpretations of similar scale features ...
R.S. Musk, J.R. Britton, S.N. Axford
doaj   +3 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

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