Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Definition of a High-Confidence Mitochondrial Proteome at Quantitative Scale
, 2017 Marcel Morgenstern +17 more
openalex +1 more source
Simulating galaxies in the reionization era with FIRE-2: galaxy scaling relations, stellar mass functions, and luminosity functions [PDF]
, 2018 Xiangcheng Ma +8 more
openalex +1 more source
Identity-by-descent detection across 487,409 British samples reveals fine scale population structure and ultra-rare variant associations [PDF]
, 2020 Juba Nait Saada +6 more
openalex +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Resilience trade-offs: addressing multiple scales and temporal aspects of urban resilience
, 2015 Lorenzo Chelleri +3 more
openalex +1 more source
LoRa Communications as an Enabler for Internet of Drones towards Large-Scale Livestock Monitoring in Rural Farms [PDF]
, 2021 Mehran Behjati +5 more
openalex +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Barely visible impact damage in scaled composite laminates: Experiments and numerical simulations [PDF]
, 2017 Xiaochuan Sun, Stephen R. Hallett
openalex +1 more source