Results 61 to 70 of about 18,403 (266)
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
SciPost PhysicsWe study the ferromagnetic transverse-field Ising model with quenched disorder at $T = 0$ in one and two dimensions by means of stochastic series expansion quantum Monte Carlo simulations using a rigorous zero-temperature scheme.
Calvin Krämer, Jan Alexander Koziol, Anja Langheld, Max Hörmann, Kai Phillip Schmidt
doaj +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Global and regional brain metabolic scaling and its functional consequences
BMC Biology, 2007 Background Information processing in the brain requires large amounts of metabolic energy, the spatial distribution of which is highly heterogeneous, reflecting the complex activity patterns in the mammalian brain.
Karbowski Jan
doaj +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Correlators in phase-ordering from Schrodinger-invariance
Nuclear Physics BSystems undergoing phase-ordering kinetics after a quench into the ordered phase with ...
Malte Henkel, Stoimen Stoimenov
doaj +1 more source
Multi-Dimensional Plant Element Stoichiometry—Looking Beyond Carbon, Nitrogen, and Phosphorus
Frontiers in Plant Science, 2020 Nutrient elements are important for plant growth. Element stoichiometry considers the balance between different nutrients and how this balance is affected by the environment.
Göran I. Ågren, Martin Weih
doaj +1 more source
Cavity-renormalized quantum criticality in a honeycomb bilayer antiferromagnet
Communications Physics, 2023 Strong light-matter interactions as realized in an optical cavity provide a tantalizing opportunity to control the properties of condensed matter systems. Inspired by experimental advances in cavity quantum electrodynamics and the fabrication and control
Lukas Weber +4 more
doaj +1 more source
Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control
FEBS Open Bio, EarlyView.Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada +5 more
wiley +1 more source