Results 91 to 100 of about 28,638 (292)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Precipitation in Al-Zr-Sc alloys: a comparison between kinetic Monte Carlo, cluster dynamics and classical nucleation theory [PDF]

, 2005
Zr and Sc precipitate in aluminum alloys to form the Al\_3Zr\_xSc\_{1-x} compound which, for low supersaturations of the solid solution, exhibits the L1\_2 structure.
Barbu, Alain, Clouet, Emmanuel, Martin, Georges, Nastar, Maylise, Sigli, Christophe   +4 more
core   +2 more sources

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Thermionic emission microscopy of scandium thin film dewetting on W(100)

AIP Advances, 2018
Scandium thin films of 5-30 nm thickness deposited on clean W(100) surfaces de-wet from the tungsten surface when heated to temperatures < 0.5 Tmelt. The dewetting temperature and the resulting droplet size are a function of the initial scandium film ...
Michael Mroz, Samuel Tenney, Tatiana Savina, Martin E. Kordesch   +3 more
doaj   +1 more source

The loss of anisotropy in MgB2 with Sc substitution and its relationship with the critical temperature

, 2005
The electrical conductivity anisotropy of the sigma-bands is calculated for the (Mg,Sc)B2 system using a virtual crystal model. Our results reveal that anisotropy drops with relatively little scandium content (< 30%); this behaviour coincides with the ...
, Blaha P Schwarz K Madsen G K H Kvasnicka D Luitz J Schwarz K, Canfield P C, de la Mora P, Gustavo Tavizon, Pablo de la Mora, Sabina Ruiz-Chavarria, Samsonov G V   +7 more
core   +1 more source

Scandium 51

Zeitschrift für Naturforschung A, 1966
Previously unreported decay characteristics of 51Sc are studied. The activity was obtained from a series of bombardments of an enriched 48Ca target (in the carbonate form) with 18 MeV α particles, β ray measurement of the investigated sample indicated a component of ~ 5 MeV endpoint energy which decays with a half life of 12 sec.
SONA, ANNA MARIA, R. Messlinger, H. Morinaga   +2 more
openaire   +2 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Solvent extraction of Sc(III) from sulfuric acid solution by bis (2-ethylhexyl) phosphinic acid in toluene [PDF]

Journal of the Serbian Chemical Society, 2002
Liquid-liquid extraction of scandium(III) from sulfuric acid solution using bis(2-ethylhexyl) phosphinic acid (PIA-8) in toluene has been studied. The extraction of scandium(III) was found to be quantitative with 0.03 M PIA-8 in toluene in the acidic ...
PURSHOTTAM M. DHADKE, DEVENDRA V. KOLADKAR   +1 more
doaj