Results 71 to 80 of about 13,195 (290)

Surface enhancement on TIG welded dissimilar Al-Mg alloy with ER5356 and scandium composites filler rod

open access: yesMaterials Research Express
The effect of different process parameters on Tungsten Inert Gas (TIG) welded dissimilar aluminium magnesium alloy AA5083-H111 and AA5052-H32 by using ER5356 filler rod and scandium added ER5356 composites is investigated in this research.
R Ashok Raj   +3 more
doaj   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

open access: yesMolecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh   +11 more
wiley   +1 more source

Petrochemical characteristics of ancient weathering crusts with scandium concentrations in the Nakyn kimberlite field

open access: yesИзвестия высших учебных заведений: Геология и разведка
Background. The study examines the petrochemical characteristics of clayey deposits from the Dyakhtar Formation in the Nakyn Kimberlite Field, which contain material from redeposited weathering crusts of the Late Triassic to the Early Jurassic age ...
R. U. Eremenko   +2 more
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

open access: yesMolecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico   +5 more
wiley   +1 more source

Scandium-Terminal Boronylphosphinidene Complex

open access: yes, 2021
International audienceThe first isolation and structural characterization of a rare-earth metal-terminal imido complex were reported in 2010, but a rare-earth metal-terminal phosphinidene complex is still absent, to date.
Feng, Bin   +5 more
core   +1 more source

On scandium [PDF]

open access: yesProceedings of the Royal Society of London. Series A, Containing Papers of a Mathematical and Physical Character, 1908
Abstract Scandia is one of the rarest and least known of the recognised rare earths. It was discovered in 1879 by Nilson, who separated it, together with ytterbia, from erbia extracted from euxenite and gadolinite. Later in the same year Cleve extracted scandia from gadolinite, yttrotitanite, and keilhauite, and described the scandium
openaire   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

open access: yesMolecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault   +12 more
wiley   +1 more source

First Principle Study of Structural, Electronic, Optical, and Thermodynamic Properties of Scandium-Doped Zirconia Zr1−xScxO2,x=0.125

open access: yesAdvances in Condensed Matter Physics
The effect of scandium doping on the structural, electronic, optical, and thermodynamic properties of scandium-doped zirconia (Zr0.875Sc0.125 O1.9375) was investigated by first-principles calculations.
Lemessa Asefa Eressa   +1 more
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim   +17 more
wiley   +1 more source

The C‐terminal region of KIF26B is indispensable for nephron progenitor condensation and kidney formation in mice

open access: yesFEBS Open Bio, EarlyView.
KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura   +19 more
wiley   +1 more source

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