Results 51 to 60 of about 2,240,629 (329)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

Efficient Simulation Method for High Quality SAR Images of Complex Ground Vehicles

open access: yesLeida xuebao, 2015
Aiming at meeting the requirement of the amass high-quality SAR images needed by template-based ground target recognition engineering practice, a novel efficient SAR signal level simulation method is proposed.
Dong Chun-zhu   +3 more
doaj  

Evaluation of the Trapped Surface Wave of a Vertical Electric Dipole Based on Undetermined Coefficient Method in the Presence of N-Layered Region: A Graphical Approach

open access: yesInternational Journal of Antennas and Propagation, 2019
In previous studies, the trapped surface wave, which is defined by the residue sums, has been addressed in the evaluation of the Sommerfeld integrals describing electromagnetic field of a vertical dipole in the presence of three-layered or four-layered ...
Hong Lei Xu   +5 more
doaj   +1 more source

The Neutron Macromolecular Crystallography Instruments at Oak Ridge National Laboratory: Advances, Challenges, and Opportunities

open access: yesCrystals, 2018
The IMAGINE and MaNDi instruments, located at Oak Ridge National Laboratory High Flux Isotope Reactor and Spallation Neutron Source, respectively, are powerful tools for determining the positions of hydrogen atoms in biological macromolecules and their ...
Flora Meilleur   +4 more
doaj   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

open access: yesMolecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia   +9 more
wiley   +1 more source

Order-disorder in room-temperature ionic liquids probed via methyl quantum tunneling

open access: yesStructural Dynamics, 2021
Room-temperature ionic liquids are promising candidates for applications ranging from electrolytes for energy storage devices to lubricants for food and cellulose processing to compounds for pharmaceutics, biotransformation, and biopreservation.
Eugene Mamontov   +2 more
doaj   +1 more source

Entanglement and Timing-Based Mechanisms in the Coherent Control of Scattering Processes

open access: yes, 2007
The coherent control of scattering processes is considered, with electron impact dissociation of H$_2^+$ used as an example. The physical mechanism underlying coherently controlled stationary state scattering is exposed by analyzing a control scenario ...
A. Abrashkevich   +31 more
core   +1 more source

Some applications of the Faddeev-Yakubovsky equations to the cold-atom physics [PDF]

open access: yes, 2011
We present some recent applications of the Faddeev--Yakubovsky equations in describing atomic bound and scattering problems. We consider the scattering of a charged particle $X$ by atomic hydrogen with special interest in $X=p,e^{\pm}$, systems of cold ...
Arnoldas Deltuva   +57 more
core   +4 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Scattering series in mobility problem for suspensions

open access: yes, 2012
The mobility problem for suspension of spherical particles immersed in an arbitrary flow of a viscous, incompressible fluid is considered in the regime of low Reynolds numbers.
Cichocki B   +11 more
core   +1 more source

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