Results 21 to 30 of about 72,710 (257)

Scavenger Receptors and Their Potential as Therapeutic Targets in the Treatment of Cardiovascular Disease

International Journal of Hypertension, 2010
Scavenger receptors act as membrane-bound and soluble proteins that bind to macromolecular complexes and pathogens. This diverse supergroup of proteins mediates binding to modified lipoprotein particles which regulate the initiation and progression of ...
Sam L. Stephen, Katie Freestone, Sarah Dunn, Michael W. Twigg, Shervanthi Homer-Vanniasinkam, John H. Walker, Stephen B. Wheatcroft, Sreenivasan Ponnambalam   +7 more
doaj   +1 more source

Effect of human scavenger receptor class A overexpression in bone marrow-derived cells on lipoprotein metabolism and atherosclerosis in low density lipoprotein receptor knockout mice

Journal of Lipid Research, 2000
Scavenger receptors, which include various classes, play an important role in atherogenesis by mediating the unrestricted uptake of modified lipoproteins, resulting in the massive accumulation of cholesteryl esters.
Nicole Herijgers, Menno P.J. de Winther, Miranda Van Eck, Louis M. Havekes, Marten H. Hofker, Peter M. Hoogerbrugge, Theo J.C. Van Berkel   +6 more
doaj   +1 more source

Scavenger receptor mediates systemic RNA interference in ticks. [PDF]

PLoS ONE, 2011
RNA interference is an efficient method to silence gene and protein expressions. Here, the class B scavenger receptor CD36 (SRB) mediated the uptake of exogenous dsRNAs in the induction of the RNAi responses in ticks.
Kyaw Min Aung, Damdinsuren Boldbaatar, Rika Umemiya-Shirafuji, Min Liao, Xuan Xuenan, Hiroshi Suzuki, Remil Linggatong Galay, Tetsuya Tanaka, Kozo Fujisaki   +8 more
doaj   +1 more source

Phagocytosis by macrophages depends on histamine H2 receptor signaling and scavenger receptor 1

MicrobiologyOpen, 2019
The histamine H2 receptor (H2R) is a G protein‐coupled receptor that mediates cyclic AMP production, protein kinase A activation, and MAP kinase signaling.
Robert Fultz, Melinda A. Engevik, Zhongcheng Shi, Anne Hall, Beatrice Herrmann, Bhanu P. Ganesh, Angela Major, Anthony Haag, Yuko Mori‐Akiyama, James Versalovic   +9 more
doaj   +1 more source

Cell density can affect cholesteryl ester accumulation in the human THP-1 macrophage.

Journal of Lipid Research, 1994
Esterified cholesterol (EC) accumulation was induced in THP-1 macrophages after exposure to acetylated LDL (acLDL), and the extent of accumulation was dependent on cell density.
A Rodriguez, S D Kafonek, A Georgopoulos, P S Bachorik   +3 more
doaj   +1 more source

Macrophage SR-BI regulates LPS-induced pro-inflammatory signaling in mice and isolated macrophages

Journal of Lipid Research, 2012
Scavenger receptor BI (SR-BI), an HDL receptor, plays a key role in reverse cholesterol transport. In mice, disruption of SR-BI results in hypersensitivity to lipopolysaccharide (LPS) and bacteria-induced septic shock due to adrenal insufficiency and ...
Lei Cai, Zhen Wang, Jason M. Meyer, Ailing Ji, Deneys R. van der Westhuyzen   +4 more
doaj   +1 more source

Modulation of macrophage scavenger receptor transport by protein phosphorylation

Journal of Lipid Research, 1996
The identification of three highly conserved phosphorylation sites in the cytoplasmic domain of each of the monomeric subunits of the macrophage scavenger receptor suggests that protein phosphorylation may regulate this receptor pathway.
L G Fong
doaj   +1 more source

Tissue Levels of CD80, CD163 and CD206 and Their Ratios in Periodontal and Peri-Implant Health and Disease

Current Issues in Molecular Biology, 2022
This study aimed to compare tissue levels of CD80 (pro-inflammatory macrophage-related surface marker), CD163, and CD206 (anti-inflammatory macrophage-related surface markers), and their ratios in periodontal and peri-implant health and disease ...
Mustafa Yilmaz, Esra Demir, Yigit Firatli, Erhan Firatli, Ulvi Kahraman Gürsoy   +4 more
doaj   +1 more source

Structures and high and low affinity ligand binding properties of murine type I and type II macrophage scavenger receptors

Journal of Lipid Research, 1993
Macrophage scavenger receptors have been implicated in various macrophage-associated processes, including atherosclerosis and clearance of bacterial endotoxin. They bind to a wide variety of polyanionic ligands and display complex binding characteristics.
J Ashkenas, M Penman, E Vasile, S Acton, M Freeman, M Krieger   +5 more
doaj   +1 more source

Scavenger Receptor CD163 and Its Biological Functions

Acta Medica, 2009
CD163 is a member of scavenger receptor super family class B of the first subgroup. It is mapped to the region p13 on chromosome 12. Five different isoforms of CD163 have been described, which differ in the structure of their cytoplasmic domains and ...
Gabriela Onofre, Martina Koláčková, Karolína Jankovičová, Jan Krejsek   +3 more
doaj   +1 more source