Results 281 to 290 of about 874,973 (319)
Some of the next articles are maybe not open access.
The cellular biology of scavenger receptor class B type I
Current Opinion in Lipidology, 2001The HDL receptor scavenger receptor class B type I plays an important role in meditating the uptake of HDL-derived cholesterol and cholesteryl ester in the liver and steroidogenic tissues. However, the mechanism by which scavenger receptor class B type I mediates selective cholesterol uptake is unclear.
David L. Silver, Alan R. Tall
openaire +3 more sources
Scavenger receptor class B type I and immune dysfunctions
Current Opinion in Endocrinology, Diabetes & Obesity, 2014To summarize the recent findings about the roles of scavenger receptor class B type I (SR-BI) in immunity and discuss the underlying mechanisms by which SR-BI prevents immune dysfunctions.SR-BI is well known as a high-density lipoprotein (HDL) receptor playing key roles in HDL metabolism and in protection against atherosclerosis.
Zhong Zheng, Junting Ai, Xiang-An Li
openaire +3 more sources
Functions of scavenger receptor class B, type I in atherosclerosis
Current Opinion in Lipidology, 2012This review highlights the diverse roles of the high-affinity HDL receptor scavenger receptor class B, type I (SR-BI) in the modulation of global cholesterol homeostasis and vascular cell function, and the potential implications of these processes in atherosclerosis.SR-BI in the liver plays a critical role in reverse cholesterol transport and it ...
Chieko Mineo, Philip W. Shaul
openaire +2 more sources
HDL scavenger receptor class B type I and platelet function
Current Opinion in Lipidology, 2011HDL cholesterol levels have been inversely correlated with thrombosis and HDL has been shown to mediate various antithrombotic effects. However, molecular mechanisms underlying the suppressing effect of HDL on platelet reactivity are not completely understood.
Jerzy-Roch Nofer, Miranda Van Eck
openaire +2 more sources
Scavenger Receptor Class B, Type I: A Promising Immunotherapy Target
Immunotherapy, 2011Scavenger receptor class B, type I (SR-BI) is a crucial molecule in lipid metabolism, since the interaction of high-density lipoproteins (HDLs) with SR-BI is involved in reverse cholesterol transport and cholesterol efflux. Recent findings also underscore a critical role of SR-BI in antimicrobial and immune responses. SR-BI is not only highly expressed
Jessica Fioravanti +2 more
openaire +3 more sources
HDL and Scavenger Receptor Class B Type I (SRBI)
2022The scavenger receptor class B type I (SR-BI) is a versatile HDL receptor protein. It is highly expressed in liver and steroidogenic tissues. SR-BI regulates selective uptake of cholesterol ester (CE) from HDL, revealing its role in mediating reverse cholesterol transport (RCT) and steroid hormone synthesis.
openaire +2 more sources
Interaction of scavenger receptor class B type I with peroxisomal targeting receptor Pex5p
Biochemical and Biophysical Research Communications, 2003Scavenger receptor class B type I (SR-BI) is an HDL receptor that mediates selective HDL lipid uptake. Peroxisomes play an important role in lipid metabolism and peroxisomal targeting signal type 1 (PTS1)-containing proteins are translocated to peroxisomes by the peroxisomal targeting import receptor, Pex5p.
Jenny M. Johansson +6 more
openaire +3 more sources
Activation of the rat scavenger receptor class B type I gene by PPARα
Molecular and Cellular Endocrinology, 2006Peroxisomal proliferator activated receptor alpha (PPARalpha) is activated by fibrate drugs which are known to protect against atherosclerosis. The present study examines the effects of PPARalpha on SR-BI expression. For this study, a rat SR-BI promoter-luciferase reporter gene construct was co-transfected into different cell lines with expression ...
Mark P. McLean, Dayami Lopez
openaire +3 more sources
Hyperglycemia suppresses hepatic scavenger receptor class B type I expression
American Journal of Physiology-Endocrinology and Metabolism, 2008Hyperglycemia is a major risk factor for atherosclerotic disease. Hepatic scavenger receptor class B type I (SR-BI) binds HDL particles that mediate reverse cholesterol transport and thus lowers the risk of atherosclerosis. Here we examined glucose regulation of SR-BI gene expression in both HepG2 cells and whole animals. Results showed that hepatic SR-
Takamasa Nishiuchi +8 more
openaire +2 more sources
Expression of scavenger receptor class B type I in gallbladder columnar epithelium
Journal of Gastroenterology and Hepatology, 2002AbstractBackgroundThe lipid content of bile may be modified by the gallbladder epithelium. Recent studies indicate that cholesterol can be absorbed from bile and that this can be enhanced by apolipoprotein (apo) A‐I. SR‐BI is a multifunctional receptor capable of binding a wide array of native or modified lipoproteins, phospholipid or bile acid ...
Jan Borén +5 more
openaire +3 more sources