Results 281 to 290 of about 103,100 (354)
Aggregate, EarlyView.This work describes a biomimetic extracellular vesicle‐spherical nucleic acid (BEV‐SNA) platform for idiopathic pulmonary fibrosis (IPF) therapy. BEV‐SNA is composed of mechanically extruded BEVs from primary MSCs and cholesterol‐modified ssDNA that are assembled through hydrophobic interactions.
Saiyun Lou +11 more
wiley +1 more source
Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.OxSpred, an eXtreme‐Gradient‐Boosting‐‐based supervised learning model, accurately annotates oxidative stress in innate immune cells at the single‐cell level, providing interpretable embeddings with significant biological relevance. This innovative tool revolutionizes the understanding of innate immune cell functions during inflammation and enhances ...
Po‐Yuan Chen, Tai‐Ming Ko
wiley +1 more source
Animal Models and Experimental Medicine, EarlyView.The experimental type 2 diabetes model in rats induced by streptozotocin and nicotinamide showed that silver nanoparticles synthesized from lemongrass extract modulate blood glucose, water and food intake, and enhance antioxidant enzyme synthesis and weight gains.
Milad Faraji +6 more
wiley +1 more source
Respiratory virus mRNA vaccines: mRNA Design, clinical studies, and future challenges
Animal Models and Experimental Medicine, EarlyView.Abstract Respiratory infectious diseases frequently erupt on a global scale, with RNA viruses, such as SARS‐CoV‐2, RSV, and influenza viruses, posing challenges to vaccine development due to their high mutation rates. Traditional vaccine development cycles are lengthy and struggle to keep pace with rapidly evolving viruses, whereas messenger RNA (mRNA)
Linlin Zheng, Han Feng
wiley +1 more source
Angewandte Chemie, EarlyView.A novel polarity‐sensitive fluorescent probe was developed for the selective targeting of lipid droplets, enabling precise visualization and quantification of lipid metabolism disorders using an integrated STED‐FLIM platform. This probe allows accurate monitoring of lipid metabolism in cellular and pathological contexts, such as atherosclerosis ...
Shixian Cao +7 more
wiley +2 more sources
Towards Polymer Composite‐Based Transient Electronic Systems
Advanced NanoBiomed Research, EarlyView.Biodegradable electronic systems are gaining attention for implantable biomedical applications, targeting disease treatment and lifespan extension. This review covers advances in biocompatible, biodegradable polymer composites using synthetic and natural polymers with conductive, semiconductive, and insulating fillers.
Gwan‐Jin Ko +5 more
wiley +1 more source
Cationic Nanoparticles Mitigate Chemotherapy‐Induced Peripheral Neuropathy
Advanced NanoBiomed Research, EarlyView.Chemotherapy‐induced peripheral neuropathy (CIPN), caused by chemodrugs like paclitaxel (PTX), leads to severe neuropathic pain. This study evaluates PTX‐loaded PAMAM‐Chol nanoparticles (PTX‐NPs) to alleviate CIPN. PTX‐NPs achieve 99% drug‐loading efficiency, reduce neurotoxicity, and in murine models, decrease cold allodynia by 85% while restoring ...
Divya Bhansali +7 more
wiley +1 more source
Angewandte Chemie, EarlyView.Human H ferritin (HuHf) is a nanocarrier for anticancer metal drugs. By cryo‐EM, a 1.51 Å structure of its adduct with Au(NHC)Cl was solved, showing a novel tetranuclear gold(I) cluster bound to Cys90 and Cys102. Short inter‐metal distances indicate aurophilic interactions.
Lucrezia Cosottini +9 more
wiley +2 more sources