Results 261 to 270 of about 55,191 (290)

Scavenger Receptor Class B, Type I: A Promising Immunotherapy Target

Immunotherapy, 2011
Scavenger receptor class B, type I (SR-BI) is a crucial molecule in lipid metabolism, since the interaction of high-density lipoproteins (HDLs) with SR-BI is involved in reverse cholesterol transport and cholesterol efflux. Recent findings also underscore a critical role of SR-BI in antimicrobial and immune responses. SR-BI is not only highly expressed
Jessica, Fioravanti, José, Medina-Echeverz, Pedro, Berraondo   +2 more
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Hyperglycemia suppresses hepatic scavenger receptor class B type I expression

American Journal of Physiology-Endocrinology and Metabolism, 2008
Hyperglycemia is a major risk factor for atherosclerotic disease. Hepatic scavenger receptor class B type I (SR-BI) binds HDL particles that mediate reverse cholesterol transport and thus lowers the risk of atherosclerosis. Here we examined glucose regulation of SR-BI gene expression in both HepG2 cells and whole animals. Results showed that hepatic SR-
Koji, Murao, Xiao, Yu, Hitomi, Imachi, Wen M, Cao, Ke, Chen, Kensuke, Matsumoto, Takamasa, Nishiuchi, Norman C W, Wong, Toshihiko, Ishida   +8 more
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Functions of scavenger receptor class B, type I in atherosclerosis

Current Opinion in Lipidology, 2012
This review highlights the diverse roles of the high-affinity HDL receptor scavenger receptor class B, type I (SR-BI) in the modulation of global cholesterol homeostasis and vascular cell function, and the potential implications of these processes in atherosclerosis.SR-BI in the liver plays a critical role in reverse cholesterol transport and it ...
Chieko, Mineo, Philip W, Shaul
openaire   +2 more sources

Scavenger receptor class B type I polymorphisms and peripheral arterial disease

Metabolism, 2007
Genetic variations of the scavenger receptor class B type I (SR-BI) have been demonstrated to be associated with plasma lipid parameters, anthropomorphic parameters, and coronary artery disease. We determined the frequency of 3 single-nucleotide polymorphisms within the SR-BI gene (SCARB1) in 354 patients with peripheral arterial disease (PAD) and 354 ...
Andreas, Ritsch, Gudrun, Sonderegger, Gudron, Sonderegger, Anton, Sandhofer, Ursula, Stanzl, Ursala, Stanzl, Ivan, Tancevski, Philipp, Eller, Wilfried, Schgoer, Andreas, Wehinger, Thomas, Mueller, Meinhard, Haltmayer, Josef R, Patsch, Joseph R, Patsch   +13 more
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Interaction of scavenger receptor class B type I with peroxisomal targeting receptor Pex5p

Biochemical and Biophysical Research Communications, 2003
Scavenger receptor class B type I (SR-BI) is an HDL receptor that mediates selective HDL lipid uptake. Peroxisomes play an important role in lipid metabolism and peroxisomal targeting signal type 1 (PTS1)-containing proteins are translocated to peroxisomes by the peroxisomal targeting import receptor, Pex5p.
Magnus S C, Johnson, Jenny M, Johansson, Per Arne, Svensson, Maria A I, Aberg, Peter S, Eriksson, Lena M S, Carlsson, Björn, Carlsson   +6 more
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Expression of scavenger receptor class B type I in gallbladder columnar epithelium

Journal of Gastroenterology and Hepatology, 2002
AbstractBackgroundThe lipid content of bile may be modified by the gallbladder epithelium. Recent studies indicate that cholesterol can be absorbed from bile and that this can be enhanced by apolipoprotein (apo) A‐I. SR‐BI is a multifunctional receptor capable of binding a wide array of native or modified lipoproteins, phospholipid or bile acid ...
Magnus S C, Johnson, Per-Arne, Svensson, Jan, Borén, Håkan, Billig, Lena M S, Carlsson, Björn, Carlsson   +5 more
openaire   +2 more sources

AGEs inhibit scavenger receptor class B type I gene expression via Smad1 in HUVECs

Journal of Molecular Endocrinology, 2021
Vascular complications are the main cause of morbidity and mortality in diabetic patients, and advanced glycation end products (AGEs) play a critical role in promoting diabetic vascular dysfunction. The human homolog of scavenger receptor class B type I (SR-BI), CD36, and LIMPII analog-1 (hSR-BI/CLA-1) facilitates the cellular uptake of cholesterol ...
Hiromi, Nagata, Jingya, Lyu, Hitomi, Imachi, Kensaku, Fukunaga, Seisuke, Sato, Toshihiro, Kobayashi, Takanobu, Saheki, Kayoko, Seo, Japar B, Salimah, Hisakazu, Iwama, Ryuichi, Sakamoto, Yoshihiro, Ogawa, Koji, Murao   +12 more
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Activation of the rat scavenger receptor class B type I gene by PPARα

Molecular and Cellular Endocrinology, 2006
Peroxisomal proliferator activated receptor alpha (PPARalpha) is activated by fibrate drugs which are known to protect against atherosclerosis. The present study examines the effects of PPARalpha on SR-BI expression. For this study, a rat SR-BI promoter-luciferase reporter gene construct was co-transfected into different cell lines with expression ...
Dayami, Lopez, Mark P, McLean
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Characterization of scavenger receptor class B, type I in Atlantic salmon (Salmo salar L.)

Lipids, 2006
AbstractThe scavenger receptor class B, type I (SR‐BI) is an important player in regulation of mammalian lipid homeostasis. We therefore wanted to study this receptor in Atlantic salmon (Salmo salar L.), which requires a diet with particular high lipid content. We have for the first time cloned and characterized SR‐BI from a salmonid fish.
E J, Kleveland, B L, Syvertsen, B, Ruyter, A, Vegusdal, S M, Jørgensen, T, Gjøen   +5 more
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Scavenger Receptor Class B Type I Modulates Epileptic Seizures and Receptor α2δ-1 Expression

Neurochemical Research
Scavenger receptor class B type I (SR-BI) is abundant in adult mouse and human brains, but its function in the central nervous system (CNS) remains unclear. This study explored the role of SR-BI in epilepsy and its possible underlying mechanism. Expression patterns of SR-BI in the brains of mice with kainic acid (KA)-induced epilepsy were detected ...
Yunyi, Huang, Yuan, Gao, Zhongwen, Huang, Minxue, Liang, Yangmei, Chen   +4 more
openaire   +2 more sources