Results 101 to 110 of about 620,119 (261)
Advanced Robotics Research, EarlyView.This review identifies key design considerations for insect‐inspired microrobots capable of multimodal locomotion. To draw inspiration, biological and robotic strategies for moving in air, on water surfaces, and underwater are examined, along with approaches for crossing the air–water interface.
Mija Jovchevska +2 more
wiley +1 more source
Identification of Scavenger Receptor Ligands
, 2011 Scavenger receptors (SRs) are structurally diverse but functionally related innate immune receptors involved in defence and clearance mechanisms. Their broad specificity relies on evolutionarily conserved pattern recognition domains which interact with a variety of microbial, apoptotic and modified self ligands.
Neyen, C, Pluddemann, A, Gordon, S
openaire +3 more sources
Advanced Science, EarlyView.Pancreatic adenocarcinoma (PAAD) remains highly lethal with limited treatment options. This study demonstrates that coixenolide, a bioactive compound from Coix lacryma‐jobi L. and a key component of the clinically approved Kanglaite injection, exhibits enhanced antitumor efficacy in high‐fat diet (HFD)‐induced obese mice bearing PAAD tumors compared to
Kaidi Chen +20 more
wiley +1 more source
Advanced Science, EarlyView.The role of TNFα in the process of renal allograft interstitial fibrosis is complex and multifaceted. As it can promote renal allograft interstitial fibrosis by inducing mitochondrial dysfunction and EndMT, and also mediating compensatory mitophagy through the NEDD4–HIF‐1α–BNIP3 pathway, which clears damaged mitochondria and inhibits EndMT, thereby ...
Dengyuan Feng +15 more
wiley +1 more source
A guide to bioinformatics for immunologists
Frontiers in Immunology, 2013 Bioinformatics includes a suite of methods, which are cheap, approachable, and many of which are easily accessible without any sort of specialized bioinformatic training. Yet, despite this, bioinformatic tools are under-utilized by immunologists. Herein,
Fiona Jane Whelan +4 more
doaj +1 more source
Scavenger Receptors in Atherosclerosis [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2000 The existence of a cell surface receptor, now known as the macrophage scavenger receptor A I/II (MSR-A), was inferred from early studies based on ligand binding analyses. Description of this binding activity, with acetylated low density lipoprotein (LDL) used as a ligand, was important because it provided a mechanism for the formation of foam cells in ...
openaire +1 more source
Innate Immunocompetent hiPSC‐Derived Neurospheroids Capture Early CNS Responses to rAAV
Advanced Science, EarlyView.Knowledge of human CNS immune responses to AAV‐based gene therapies remains limited due to the lack of immune‐competent human models. Here, a hiPSC‐derived 3D neuroimmune platform integrating neurospheroids and microglia is established using stirred‐tank bioreactors.
Catarina M. Gomes +14 more
wiley +1 more source
SP-A binds Scavenger Receptors.
, 2013 FITC-labeled SP-A was incubated with immobilized bovine serum albumin (BSA) or purified SRA-I, SRA-II, or MARCO. SP-A was able to bind to all three scavenger receptors suggesting a means to enhance phagocytosis of flagellated bacteria; n=3 ...
Chinhong Lin (491545) +3 more
core +1 more source
Inhibition of Mitogen-Activated Protein Kinase Erk1/2 Promotes Protein Degradation of ATP Binding Cassette Transporters A1 and G1 in CHO and in HuH7 cells. [PDF]
, 2013 Signal transduction modulates expression and activity of cholesterol transporters. We recently demonstrated that the Ras/mitogen-activated protein kinase (MAPK) signaling cascade regulates protein stability of Scavenger Receptor BI (SR-BI) through ...
Enrich Bastús, Carles +41 more
core +2 more sources
Advanced Science, EarlyView.Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang +6 more
wiley +1 more source