Results 271 to 280 of about 53,181 (303)

Scavenger Receptors, Oxidized LDL, and Atherosclerosis

Annals of the New York Academy of Sciences, 2001
Abstract: Oxidized LDL (OxLDL) competes with oxidatively damaged and apoptotic cells for binding to mouse peritoneal macrophages, implying the presence of one or more common domains. However, the nature of the ligands involved has not been determined.
Joseph L. Witztum, Oswald Quehenberger, Peter X. Shaw, Wulf Palinski, David A. Bird, Agnès Boullier, Mi-Kyung Chang, Daniel Steinberg, Kristin Gillotte-Taylor, Sohvi Hörkkö, Valeska Terpstra, Edward A. Dennis, Peter Friedman   +12 more
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Scavenging for receptors [PDF]

Nature, 1990
Joseph L. Goldstein, Michael S. Brown
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New scavenger receptors and their functions in atherogenesis

Current Atherosclerosis Reports, 2002
LOX-1 may play important roles in oxLDL-induced apoptosis of intimal VSMC. Although multiple molecules may be involved in oxLDL uptake in macrophages, SR-PSOX might contribute to oxLDL-induced accumulation of cholesteryl ester in macrophages. These biologic functions of LOX-1 and SR-PSOX may stimulate atherosclerotic plaque rupture. Future studies with
Toru Kita, Noriaki Kume
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Class A scavenger receptors, macrophages, and atherosclerosis

Current Opinion in Lipidology, 2001
The scope of this review is to discuss the new advances in our understanding of the role of scavenger receptor class A in the initiation and modulation of the atherosclerotic process. Through the approaches of gene manipulation in the mouse model, a substantial body of literature has accumulated that depicts scavenger receptor class A as a central ...
Sergio Fazio, MacRae F. Linton
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Characterization of the Hepatic Scavenger Receptor

1987
The hepatic scavenger receptor is a high affinity receptor on the surface of the sinusoidal endothelial cells and Kupffer cells (Nagelkerke et al., 1983; Pitas et al., 1985). it was suggested that the hepatic scavenger receptor could remove modified forms of LDL from the circulating blood and protect the arterial wall from an increased influx of ...
H Sinn, G. Schettler, H. A. Dresel, D. P. Via, E. Friedrich   +4 more
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Scavenger receptors for oxidized and glycated proteins

Amino Acids, 2003
Our present knowledge on chemically modified proteins and their receptor systems is originated from a proposal by Goldstein and Brown in 1979 for the receptor for acetylated LDL which is involved in foam cell formation, one of critical steps in atherogenesis.
Seikoh Horiuchi, Y. Sakamoto, M. Sakai
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Scavenger receptor B2 is a cellular receptor for enterovirus 71

Nature Medicine, 2009
Enterovirus 71 (EV71) belongs to human enterovirus species A of the genus Enterovirus within the family Picornaviridae. EV71, together with coxsackievirus A16 (CVA16), are most frequently associated with hand, foot and mouth disease (HFMD). Although HFMD is considered a mild exanthematous infection, infections involving EV71, but not CVA16, can ...
Takashi Minowa, Jifen Li, Nobutaka Hanagata, Taro Takemura, Yasuko Yamashita, Seiya Yamayoshi, Satoshi Koike   +6 more
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Monitoring Scavenging Activity of Chemokine Receptors

2016
Migration and positioning of cells is fundamental for complex functioning of multicellular organisms. During an immune response, cells are recruited from remote distances to a distinct location. Cells that are passively transported leave the circulation stimulated by locally produced signals and follow chemotactic cues to reach specific destinations ...
Barbara Moepps, Marcus Thelen
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Scavenger Receptor and Targeting Strategies

2019
Scavenger receptors constitute a group of receptors on the cell surface that attach to various ligands and remove the targets that are non-self or altered. Signaling, transport, endocytosis, phagocytosis, and adhesion resulting in the removal of harmful and degraded substances are some functions of these receptors.
Amit S. Lokhande, Padma V. Devarajan, Priyanka S. Jahagirdar, Prajakta Dandekar   +3 more
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The puzzling ligands for scavenger receptors

2000
The conversion of arterial macrophages to foam cells is believed to occur primarily because of the uptake of oxidatively modified LDL by one or more so-called scavenger receptors. Because atherosclerosis, being a disease confined to humans and occurring late in life, cannot exert any genetic pressure, the persistence of these genes in evolution must ...
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