Results 51 to 60 of about 469,953 (338)

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Chemical Composition and in Vitro Evaluation of the Antioxidant and Antimicrobial Activities of Eucalyptus gillii Essential Oil and Extracts [PDF]

, 2012
In this study, essential oil and various extracts (hexane, petroleum ether, acetone, ethanol, methanol and water) of Eucalyptus gilii were screened for their chemical composition, antimicrobial and antioxidant activities.
Ahmed Lebrihi, Arvouet-Grand, Brooke, Cheng, Damjanovic-Vratnica, Dorsaf Ben Hassine, Florence Mathieu, Folin, François Couderc, Giamakis, Jaimand, Jalloul Bouajila, Manef Abderrabba, Naczk, Pittman, Rahman, Sikkema, Singab, Sonboli, Ultee, Yan Yvon   +20 more
core   +5 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

scavenger

, 2014
Citation: 'scavenger' in the IUPAC Compendium of Chemical Terminology, 3rd ed.; International Union of Pure and Applied Chemistry; 2006. Online version 3.0.1, 2019. 10.1351/goldbook.S05495 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire   +2 more sources

Insights into the feeding ecology of and threats to Sand Cat Felis margarita Loche, 1858 (Mammalia: Carnivora: Felidae) in the Kyzylkum Desert, Uzbekistan

Journal of Threatened Taxa, 2019
Little is known about the ecology of the Sand Cat Felis margarita throughout its range in the deserts of northern Africa to central Asia.  We present observations of the Sand Cat in the southern Kyzylkum Desert, Uzbekistan, potentially preying upon a ...
Alex Leigh Brighten, Robert John Burnside   +1 more
doaj   +1 more source

Individual Variation in Predatory Behavior, Scavenging and Seasonal Prey Availability as Potential Drivers of Coexistence between Wolves and Bears

Diversity, 2020
Several large carnivore populations are recovering former ranges, and it is important to understand interspecific interactions between overlapping species. In Scandinavia, recent research has reported that brown bear presence influences gray wolf habitat
Andrés Ordiz, Cyril Milleret, Antonio Uzal, Barbara Zimmermann, Petter Wabakken, Camilla Wikenros, Håkan Sand, Jon E Swenson, Jonas Kindberg   +8 more
doaj   +1 more source

In-vitro antioxidant and anti-inflamatory activities of Pituranthos chloranthus and Artemisia vulgaris from Tunisia [PDF]

, 2020
Pituranthos chloranthus and Artemisia vulgaris L. are two of the most important aromatic and medicinal species from the Apiaceae and Asteraceae families, respectively. They are traditionally used in certain pathologies in which inflammatory processes are
AAZZA, Smail, Ben Nasr, Soumeya, Miguel, Maria, Mnif, Wissem   +3 more
core   +1 more source

Standardizing Scavenger Receptor Nomenclature [PDF]

The Journal of Immunology, 2014
Abstract Scavenger receptors constitute a large family of proteins that are structurally diverse and participate in a wide range of biological functions. These receptors are expressed predominantly by myeloid cells and recognize a variety of ligands, including endogenous and modified host-derived molecules and microbial pathogens.
PrabhuDas, Mercy, Bowdish, Dawn, Drickamer, Kurt, Febbraio, Maria, Herz, Joachim, Kobzik, Lester, Krieger, Monty, Loike, John D., Means, Terry K., Moestrup, Soren K., Post, Steven, Sawamura, Tatsuya, Silverstein, Samuel C., Wang, Xiang-Yang, El Khoury, Joseph   +14 more
openaire   +3 more sources

ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells

FEBS Open Bio, EarlyView.
Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori, Kohei Kawabata, Takanori Kubo, Takeo Kitazawa, Sae Kanai, Madoka Iwashita, Ami Hayashi, Hiroyuki Nishi, Mikihisa Takano   +8 more
wiley   +1 more source

Free-radical-scavenging and antioxidant capacities with special emphasis on enzyme activities and in vitro studies in Caralluma flava N. E. Br.

Biotechnology & Biotechnological Equipment, 2018
Caralluma flava is a perennial, succulent edible plant distributed in the hillsides of the United Arab Emirates. In order to validate its use in the traditional system as an edible and medicinal source, we evaluated the antioxidant and in vitro free ...
Kandhan Karthishwaran, Salem Obaid Saeed Obaid Al Shamisi, Shyam Sreedhara Kurup, Sabitha Sakkir, Abdul Jaleel Cheruth   +4 more
doaj   +1 more source