Results 111 to 120 of about 183,410 (305)
Advanced Science, EarlyView.A predictive model for 3D printability is developed by integrating rheological analysis, including the Large Amplitude Oscillatory Shear (LAOS) test, with machine learning. With prediction errors under 10%, the model shows that post‐extrusion recovery controls horizontal printability, while high‐strain‐rate nozzle flow dictates vertical printability ...
Eun Hui Jeong +7 more
wiley +1 more source
The Concept of Moral Obligation: Anscombe _contra_ Korsgaard [PDF]
, 2007 A number of recent writers have expressed scepticism about the viability of a specifically moral concept of obligation, and some of the considerations offered have been interesting and persuasive.
Alvarez, Maria
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Aberrant SUMOylation Restricts the Targetable Cancer Immunopeptidome
Advanced Science, EarlyView.Pharmacological SUMOylation inhibition (SUMOi) counteracts tumor immune evasion by unmasking an immunogenic HLA‐I peptide and neoepitope repertoire. By restoring HLA‐I ligand availability through increased antigen processing and presentation, enhanced proteasomal cleavage, and modulated TAP1 peptide affinity, SUMOi boosts tumor immunogenicity ...
Uta M. Demel +19 more
wiley +1 more source
“Policy Scepticism” and the Impact of Welsh Higher Education Institutions (HEIs) on their Host Region: Accounting for Regional Budget Constraints [PDF]
This paper replicates the analysis of Scottish HEIs in Hermannsson et al (2010b) for the case of Wales in order to provide a self-contained analysis that is readily accessible by those whose primary concern is with the regional impacts of Welsh HEIs.
Katerina Lisenkova +3 more
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Scepticism About Epistemic Blame Scepticism
EpistemeAbstract A number of philosophers have recently argued that there is such a thing as ‘epistemic blame’: blame targeted at epistemic norm violations qua epistemic norm violations. However, Smartt (2024) and Matheson and Milam (2022) have recently provided several arguments in favour of thinking epistemic blame either doesn’t exist or is never ...
openaire +1 more source
Advanced Science, EarlyView.This study demonstrates that dual UCP2/IL‐17 blockade reprograms T‐cell metabolism to overcome PDAC immunosuppression. Genipin‐mediated UCP2 inhibition enhances CD8⁺ T‐cell IFN‐γ via IL‐12R/STAT4/mTOR signaling and mitochondrial OXPHOS. Combined IL‐17 depletion amplifies Tc1/Th1 responses, reduces MDSCs, and prolongs survival in PDAC models ...
Chuan‐Teng Liu +11 more
wiley +1 more source
Literature and the Post-secular: The Case of Julian Barnes
American and British Studies Annual, 2019 The recently emerged post-secular literary studies is a response to what Jürgen Habermas dubs as ‘postsecularisation.’ While the definition of the term remains obscure, a post-secular criticism of literary texts overcomes this elusiveness by identifying
Lilia Miroshnychenko
doaj
OPTRACE: Optical Imaging–Guided Transplantation and Tracking of Cells in the Mouse Brain
Advanced Science, EarlyView.OPTRACE establishes an optical, two‐step platform for intracerebral cell therapy. Transparent glass pipettes enable real‐time, image‐guided delivery, while multiplex genetic labeling with two‐photon and bioluminescence readouts supports longitudinal single‐cell tracking and host–graft dynamics.
Jinghui Wang +10 more
wiley +1 more source
Cartesian Humility and Pyrrhonian Passivity: The Ethical Significance of Epistemic Agency [PDF]
, 2016 While the Academic sceptics followed the plausible as a criterion of truth and guided their practice by a doxastic norm, so thinking that agential performances are actions for which the agent assumes responsibility, the Pyrrhonists did not accept ...
Gómez-Alonso, Modesto
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