Results 231 to 240 of about 63,687 (336)

The Gut Microbiota in Hematologic Malignancies: Mechanisms, Clinical Associations, and Translational Opportunities. [PDF]

Nutrients
Caserta S, Martino EA, Skafi M, Vigna E, Bruzzese A, Amodio N, Fiorillo M, Lucia E, D'Arrigo G, Olivito V, Labanca C, Mendicino F, Alvaro ME, Tripepi G, Morabito F, Gentile M.   +15 more
europepmc   +1 more source

Effect of individual SCFA on the epithelial barrier of sheep rumen under physiological and acidotic luminal pH conditions.

Journal of Animal Science, 2018
Gabriel Greco, F. Hagen, Svenja Meissner, Zanming Shen, Zhongyan Lu, S. Amasheh, J. Aschenbach   +6 more
semanticscholar   +1 more source

Targeting the Gut-Heart Axis in Diabetic Heart Failure: Microbiota and SGLT2is as Converging Therapeutic Frontiers. [PDF]

Int J Mol Sci
Chu Y, Huang KH, Tseng CN.
europepmc   +1 more source

The Emerging Short Chain Fatty Acid Enriched Metabotype in Irritable Bowel Syndrome and Its Potential Clinical Relevance

Alimentary Pharmacology &Therapeutics, EarlyView.
In a cohort of IBS‐D patients recruited to the TRITON study, faecal metabolomic profiling reveals a SCFA‐enriched metabotype associated with increased pain and urgency, altered stool characteristics and accelerated intestinal transit. ABSTRACT Background Metabolomic analysis in irritable bowel syndrome (IBS) has identified metabotypes enriched in ...
T. E. Conley, A. Duncan, A. Modasia, A. C. Ford, D. M. Pritchard, F. Hildebrand, F. J. Warren, R. Spiller, C. S. Probert   +8 more
wiley   +1 more source

Dairy Bioactive Compounds as Precision Modulators of Gut Microbiota: From Molecular Mechanisms to Personalized Immunometabolic Health. [PDF]

Foods
Alhaj OA, Elsahoryi NA, Jahrami HA.
europepmc   +1 more source

Therapeutic potential of natural products in cancer immunotherapy: Advances and challenges

British Journal of Pharmacology, EarlyView.
This review systematically outlines the mechanisms underlying tumour immunotherapy resistance and elucidates the role of natural products in enhancing therapeutic efficacy as immunomodulatory adjuvants. Abstract Immunotherapy has emerged as a clinically pivotal approach in cancer treatment, but its application remains limited to a small subset of ...
Rao Hu, Kaibin Dai, Zhensheng Lin, Mingfang Ye, Minfeng Chen, Xiaobo Li, Dongmei Zhang   +6 more
wiley   +1 more source

The SCFA butyrate stimulates the epithelial production of retinoic acid via inhibition of epithelial HDAC.

American Journal of Physiology - Gastrointestinal and Liver Physiology, 2016
R. Schilderink, C. Verseijden, J. Seppen, V. Muncan, G. R. van den Brink, T. Lambers, E. V. van Tol, W. de Jonge   +7 more
semanticscholar   +1 more source

Ketogenic Diet Alleviates Colorectal Cancer by Attenuating Macrophage M2 Polarisation Triggered by Oncometabolite MMA Derived From the Gut Microbiota

Cell Proliferation, EarlyView.
Proposed mechanism of the ketogenic diet‐microbiota‐MMA‐immune axis in CRC. (Part 1) A ketogenic diet remodels gut microbiota homeostasis by depleting MMA‐producing bacteria, thereby reducing the accumulation of the oncometabolite (MMA). (Part 2) At the molecular level, MMA acts as a ligand that binds to Rap1, activating the downstream MAPK/ERK ...
Yang Lu, Bo Shi, Jinmiao Chen, Huihui Yao, Xiuwei Mi, Minke Shao, Yiyuan Zhao, Lijun Meng, Qingliang Tai, Junjie Chen, Xinyu Shi, Diyuan Zhou, Yizhou Yao, Songbing He   +13 more
wiley   +1 more source

Partially hydrolysed guar gum ameliorates murine intestinal inflammation in association with modulating luminal microbiota and SCFA

British Journal of Nutrition, 2016
T. Takagi, Y. Naito, Yasuki Higashimura, Chihiro Ushiroda, K. Mizushima, Y. Ohashi, Zenta Yasukawa, M. Ozeki, M. Tokunaga, T. Ōkubo, K. Katada, Kazuhiro Kamada, K. Uchiyama, O. Handa, Y. Itoh, T. Yoshikawa   +15 more
semanticscholar   +1 more source

Targeting the microbiota‐miRNA‐protease axis: A new therapeutic avenue in melanoma

The FEBS Journal, EarlyView.
Modulation of extracellular matrix (ECM) turnover is central to melanoma progression and metastasis, driven largely by ECM proteases. This review highlights the epigenetic regulation of ECM proteases by microRNAs and their roles in melanoma growth, invasion, and immune modulation.
Elias N. Katsoulieris, Paraskevi Ioannou, Nikolaos A. Afratis   +2 more
wiley   +1 more source