Results 151 to 160 of about 1,231,038 (365)

Robust acute myeloid leukemia engraftment in humanized scaffolds using injectable biomaterials and intravenous xenotransplantation

open access: yesMolecular Oncology, EarlyView.
Patient‐derived xenografts (PDXs) can be improved by implantation of a humanized niche. We tested different biomaterials and approaches, and demonstrate that the combination of an injectable biomaterial for scaffold creation plus an intravenous route for acute myeloid leukemia (AML) xenotransplantation provide the most convenient and robust approach to
Daniel Busa   +13 more
wiley   +1 more source

Competitive Algorithms from Competitive Equilibria: Non-Clairvoyant Scheduling under Polyhedral Constraints [PDF]

open access: yesarXiv, 2014
We introduce and study a general scheduling problem that we term the Packing Scheduling problem. In this problem, jobs can have different arrival times and sizes; a scheduler can process job $j$ at rate $x_j$, subject to arbitrary packing constraints over the set of rates ($\vec{x}$) of the outstanding jobs.
arxiv  

Targeted metabolomics reveals novel diagnostic biomarkers for colorectal cancer

open access: yesMolecular Oncology, EarlyView.
This study employed targeted metabolomic profiling to identify 302 distinct metabolites present in platelet‐rich plasma (PRP), revealing aberrant metabolic profiles amongst individuals diagnosed with colorectal cancer (CRC). Compared to carcinoembryonic antigen (CEA) and cancer antigen 19‐9 (CA199), our metabolite panel showed improved sensitivity ...
Zuojian Hu   +7 more
wiley   +1 more source

Construction Scheduling and Stability of the Resulting Schedules

open access: yesArchives of Civil Engineering, 2016
Abstract The paper present the concept of stability assessing the of solutions which are construction schedules. Rank have been obtained through the use of task scheduling rules and the application of the KASS software. The aim of the work is the choice of the equivalent solution in terms of the total time of the project.
openaire   +3 more sources

KMT2A degradation is observed in decitabine‐responsive acute lymphoblastic leukemia cells

open access: yesMolecular Oncology, EarlyView.
We demonstrate that decitabine (DEC) not only degrades the DNA methyltransferase DNMT1 but also the leukemic driver lysine methyltransferase KMT2A likely due to structural similarity of the DNA‐binding CXXC domains. DEC influences KMT2A downstream processes and synergizes with menin inhibitor revumenib (REV) to decrease leukemic cell proliferation, and
Luisa Brock   +10 more
wiley   +1 more source

Revisiting the Schedule Graph Generation for the Exact and Sustainable Analysis of Non-preemptive Scheduling [PDF]

open access: yesarXiv
This paper addresses the problem of scheduling non-preemptive tasks with release jitter and execution time variation on a uniprocessor. We show that the schedulability analysis based on schedule graph generation, proposed by Nasri and Brandenburg [RTSS 2017], produces negative results when it could be easily avoided by slightly reformalizing the notion
arxiv  

Polyfunctional CD8+CD226+RUNX2hi effector T cells are diminished in advanced stages of chronic lymphocytic leukemia

open access: yesMolecular Oncology, EarlyView.
CD226+CD8+ T cells express elevated levels of RUNX2, exhibit higher proliferation capacity, cytokines and cytolytic molecules expression, and migratory capacity. In contrast, CD226−CD8+ T cells display an exhausted phenotype associated with the increased expression of co‐inhibitory receptors and impaired effector functions.
Maryam Rezaeifar   +4 more
wiley   +1 more source

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