Results 71 to 80 of about 155,764 (269)
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
IET Collaborative Intelligent ManufacturingMatheuristic is an optimisation methodology that integrates mathematical approaches and heuristics to address intractable combinatorial optimisation problems, where a common framework is to insert mixed integer linear programming (MILP) models as local ...
Jiaxin Fan
doaj +1 more source
End-to-End Latency Optimization for Containerized ROS 2 Autonomous Driving Software
IEEE AccessOne of the most significant shifts in software development is the growing prevalence of microservice-oriented and containerized applications. However, it faces challenges regarding timing and latency optimization. We present an optimization approach that
Tobias Betz +7 more
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
CoRR, 2020 In the winter of 1976, Alexander Rinnooy Kan and Jan Karel Lenstra defended their PhD theses at the University of Amsterdam. Gene Lawler was on their committees. It was a natural idea to turn the theses into a textbook on scheduling. They set out to compile a survey with Ron Graham (1979), but progress on the book was hampered by the many research ...
Jan Karel Lenstra, David B. Shmoys
openaire +2 more sources
Predict+Optimize Problem in Renewable Energy Scheduling
IEEE AccessPredict+Optimize frameworks integrate forecasting and optimization to address real-world challenges such as renewable energy scheduling, where variability and uncertainty are critical factors.
Christoph Bergmeir +27 more
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
AxiomsSingle-machine group scheduling with general logarithmic deterioration is investigated, where the actual job processing (resp. group setup) time is a non-decreasing function of the sum of the logarithmic job processing (resp.
Jin-Da Miao +3 more
doaj +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source