Results 91 to 100 of about 275,856 (278)

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

open access: yesMolecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson   +2 more
wiley   +1 more source

Survey on Combinatorial Register Allocation and Instruction Scheduling

open access: yes, 2018
Register allocation (mapping variables to processor registers or memory) and instruction scheduling (reordering instructions to increase instruction-level parallelism) are essential tasks for generating efficient assembly code in a compiler.
Lozano, Roberto Castañeda   +1 more
core  

Joint Scheduling and ARQ for MU-MIMO Downlink in the Presence of Inter-Cell Interference

open access: yes, 2010
User scheduling and multiuser multi-antenna (MU-MIMO) transmission are at the core of high rate data-oriented downlink schemes of the next-generation of cellular systems (e.g., LTE-Advanced). Scheduling selects groups of users according to their channels
Caire, Giuseppe   +3 more
core   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

open access: yesMolecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia   +9 more
wiley   +1 more source

Real-Time Operation Scheduling Optimization of Electric-Hydrogen Coupling System Under Multiple Time Scales

open access: yes南方能源建设
[Objective] With the rapid development of new power systems, the electrc-hydrogen coupling system gradually presents the characteristics of multiple time scales, multiple uncertainties, high-dimensional multiple levels, nonlinearity, etc., which puts ...
Yu FU   +3 more
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Resource scheduling of workflow multi-instance migration based on the shuffled leapfrog algorithm

open access: yesJournal of Industrial Engineering and Management, 2015
Purpose: When the workflow changed, resource scheduling optimization in the process of the current running instance migration has become a hot issue in current workflow flexible research; purpose of the article is to investigate the resource scheduling ...
Yang Mingshun   +4 more
doaj   +1 more source

CONTRIBUTIONS TO MULTI-AGENT SYSTEMS IMPLEMENTATION FOR PROJECT SCHEDULING [PDF]

open access: yes
Increasing project complexity makes scheduling problems more difficult to solve and requires more versatile algorithms. Two different approaches for the project scheduling optimization could be considered: TCPSP (Time-Constrained Project Scheduling), and
Constanta Nicoleta BODEA   +1 more
core  

A Novel Metaheuristics To Solve Mixed Shop Scheduling Problems

open access: yes, 2013
This paper represents the metaheuristics proposed for solving a class of Shop Scheduling problem. The Bacterial Foraging Optimization algorithm is featured with Ant Colony Optimization algorithm and proposed as a natural inspired computing approach to ...
Ravibabu, V.
core   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

open access: yesMolecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad   +12 more
wiley   +1 more source

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