Results 121 to 130 of about 2,100,013 (302)

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Multi-objective two-stage robust optimization of wind/PV/thermal power system based on meta multi-agent reinforcement learning

International Journal of Electrical Power & Energy Systems
The integration of renewable energy into the power grid poses significant challenges for optimization and scheduling of the power system. In recent years, methods based on deep reinforcement learning have surpassed traditional methods on the high ...
Dengao Li, Zhuokai Zhang, Ding Feng, Yu Zhou, Xiaodong Bai, Jumin Zhao   +5 more
doaj   +1 more source

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source

Optimization of Vehicle Routing Problem with Tight Time Windows, Short travel time and Re-used Vehicles (VRPTSR) for Aircraft Refueling in Airport Using Ant Colony Optimization Algorithm

JAREE (Journal on Advanced Research in Electrical Engineering), 2018
Scheduling in aircraft refueling has an important role in aviation. Scheduling of aircraft refueling is called Airport Ground Service Scheduling (AGSS) that can be formulated as Vehicle Routing Problem with Tight time windows, Short travel time and Re ...
nurlita gamayanti
doaj  

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Cooperative spectrum sensing scheduling scheme based on discrete particle swarm optimization algorithm

Tongxin xuebao, 2017
The statistical characteristics of the network state changes were analyzed by using the CTMC model.Considering the difference of each secondary user’s sensing ability,two integer programming problems on cooperative sensing scheduling scheme were ...
Xing ZHANG, Ye WANG, Yi YANG, Qin-yu ZHANG   +3 more
doaj   +2 more sources

Application of simulated annealing algorithm in multi-objective cooperative scheduling of load and storage of source network for load side of new power system

Energy Informatics
To improve the adaptability of grid load collaborative scheduling, a multi-objective collaborative scheduling method based on a simulated annealing algorithm for the load storage of grid loads on the load side of a new power system is proposed. Local bus
Xinming Wang, Huayang Liang, Xiaobo Jia, Shihui Li, Shengyang Kang, Yan Gao   +5 more
doaj   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Approximation Results for Preemptive Stochastic Online Scheduling [PDF]

We present first constant performance guarantees for preemptive stochastic scheduling to minimize the sum of weighted completion times. For scheduling jobs with release dates on identical parallel machines we derive policies with a guaranteed performance
Megow, Nicole, Vredeveld, Tjark
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