Results 111 to 120 of about 19,773 (260)
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Approximation Results for Preemptive Stochastic Online Scheduling
We present first constant performance guarantees for preemptive stochastic scheduling to minimize the sum of weighted completion times. For scheduling jobs with release dates on identical parallel machines we derive policies with a guaranteed performance
Megow, Nicole, Vredeveld, Tjark
core
Genetic Fuzzy Scheduling - Development of Rule-based Scheduling Strategies for Parallel Machines
, 2012 International audienceIn this book, we present novel methodologies for automatically generating online scheduling strategies with the help of real life workload data. The scheduling problem includes independent parallel jobs, multiple identical machines,
Lepping, Joachim
core
Dynamic job-shop scheduling using reinforcement learning agents
, 2000 Static and dynamic scheduling methods have attracted a lot of attention in recent years. Among these, dynamic scheduling techniques handle scheduling problems where the scheduler does not possess detailed information about the jobs, which may arrive at ...
�ztemel, Ercan +2 more
core +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
An optimal procedure for the unconstrained max-NPV project scheduling problem with generalized precedence relations. [PDF]
The unconstrained max-npv project scheduling problem involves the scheduling of the activities of a project in order to maximize its net present value. Assume a project represented in activity-on-mode (AoN) notation, in which the activities have a known ...
De Reyck, B, Herroelen, Willy
core
Minimizing Makespan Scheduling on a Single Machine with General Positional Deterioration Effects
AxiomsThis work studies single-machine scheduling with general position-dependent deterioration, where job processing times are general non-decreasing functions dependent on their positions in a sequence.
Yu Sun +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Computational experience with a branch-and-bound procedure for the resource-constrained project scheduling problem with generalized precedence relations. [PDF]
In a previous paper (De Reyck and Herroelen, 1996a), we presented an optimal procedure for the resource-constrained project scheduling problem (RCPSP) with generalised precedence relations (further denoted as RCPSP-GPR) with the objective of minimizing ...
De Reyck, B, Herroelen, Willy
core