Results 61 to 70 of about 772,854 (294)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Enhanced Schema Linking with Large Language Models via Self-Verification and Value Hints

Big Data and Cognitive Computing
Schema linking, the task of identifying relevant database schema elements (tables and columns) for natural language queries, is a critical component in database-driven natural language interfaces.
Linfei Ma, Dexing Wei, Xiangpeng Li, Feng Wen, Haisu Zhang   +4 more
doaj   +1 more source

Binary Noise Guidance Learning for Remote Sensing Image-to-Image Translation

Remote Sensing, 2023
Image-to-image translation (I2IT) is an important visual task that aims to learn a mapping of images from one domain to another while preserving the representation of the content. The phenomenon known as mode collapse makes this task challenging.
Guoqing Zhang, Ruixin Zhou, Yuhui Zheng, Baozhu Li   +3 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

How do Explanations Justify?

Informal Logic
: The paper presents an extended scheme for the inference to the best explanation (IBE). The scheme precisely treats the epistemic modifiers (“hypothetically,” “plausibly,” “presumably”) of the inference, acknowledges its contrastive nature, clarifies ...
Petar Bodlović, Marcin Lewiński
doaj   +1 more source

Universal Causality

Entropy, 2023
Universal Causality is a mathematical framework based on higher-order category theory, which generalizes previous approaches based on directed graphs and regular categories.
Sridhar Mahadevan
doaj   +1 more source

Neuronal Modulation in the Prefrontal Cortex in a Transitive Inference Task: Evidence of Neuronal Correlates of Mental Schema Management

Journal of Neuroscience, 2016
When informed that A > B and B > C, humans and other animals can easily conclude that A > C. This remarkable trait of advanced animals, which allows them to manipulate knowledge flexibly to infer logical relations, has only recently garnered interest in ...
E. Brunamonti, V. Mione, F. Di Bello, P. Pani, A. Genovesio, S. Ferraina   +5 more
semanticscholar   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Dorsal Premotor Cortex Neurons Signal the Level of Choice Difficulty during Logical Decisions

Cell Reports, 2020
Summary: Studies on the neuronal correlates of decision making have demonstrated that the continuous flow of sensorial information is integrated by sensorimotor brain areas in order to select one among simultaneously represented targets and potential ...
Valentina Mione, Emiliano Brunamonti, Pierpaolo Pani, Aldo Genovesio, Stefano Ferraina   +4 more
doaj   +1 more source