Results 71 to 80 of about 772,854 (294)

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Differential representations of spatial environments in mPFC and hippocampus underpinning flexible navigation

NeuroImage
Studies on spatial schemas have primarily derived from rodent literature examining the development of task representations in the animal’s brain. However, traditional models of schema in humans have largely (although not exclusively) been non-navigation ...
Paulina Maxim, Thackery I. Brown
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Schema Inference for Tabular Data with Explainable Artificial Intelligence [PDF]

Data engineering is an integral part of the data science process. It comprises tasks such as data ingestion, data transformation, and data quality assurance. In order to fulfill these tasks, schema inference is an important capability.
Riehle, Dirk, Koch, Christian, Müller, Katharina   +2 more
core   +1 more source

Deep Hybrid Models: Infer and Plan in a Dynamic World

Entropy
To determine an optimal plan for complex tasks, one often deals with dynamic and hierarchical relationships between several entities. Traditionally, such problems are tackled with optimal control, which relies on the optimization of cost functions ...
Matteo Priorelli, Ivilin Peev Stoianov
doaj   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Schema Inference on Wikidata

, 2018
master-thesis-final.tar.gz is a tarball of the thesis' source code, from which it should be possible to build the thesis by running `make`; master-thesis-Lucas-Werkmeister.pdf is the PDF built directly by PDFLaTeX; and master-thesis-Lucas-Werkmeister-signed.pdf is a signed version of master-thesis-Lucas-Werkmeister.pdf, signed with the PortableSigner ...
openaire   +2 more sources

Vestibular Patient Journey: Insights From Vestibular Disorders Association (VeDA) Registry

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Vestibular symptoms impose a high burden of disability. Understanding real‐world diagnostic and treatment pathways can identify care gaps and guide interventions. We aimed to characterize symptom profiles, diagnostic trends, provider involvement, and treatment patterns in vestibular disorders.
Ali Rafati, Sami I. Nassar, Shaun A. Nguyen, Patricia L. Gerend, Michael C. Schubert, Michael T. Teixido, Frederick A. Godley, Joel A. Goebel, Cynthia A. Ryan, Habib G. Rizk, Amir Kheradmand   +10 more
wiley   +1 more source

Problem Decomposition Method to Compute an Optimal Cover for a Set of Functional Dependencies [PDF]

Database Systems Journal, 2011
The paper proposes a problem decomposition method for building optimal cover for a set of functional dependencies to decrease the solving time. At the beginning, the paper includes an overview of the covers of functional dependencies.
Vitalie COTELEA
doaj