Results 101 to 110 of about 270,524 (304)

'I think you understand me' : studying the associations between actual, assumed, and perceived understanding within couples [PDF]

, 2019
The current study examined the associations between actual, assumed, and perceived understanding and partners' levels of dyadic adjustment. One hundred fifty-two couples provided questionnaire data (assumed and perceived understanding), participated in a
Gistelinck, Fien, Hinnekens, Celine, Stas, Lara, Verhofstadt, Lesley   +3 more
core   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Comparison the Effectiveness of Schema Couple Therapy and Mindfulness-Based Cognitive Therapy on Marital Intimacy in Couples Exposed to Divorce

Taḥqīqāt-i ̒Ulūm-i Raftārī, 2022
Aim and Background: Marital intimacy in divorcing couples is associated with shortcomings, based on this, this research aimed to compare the effectiveness of schema couple therapy and mindfulness-based cognitive therapy on marital intimacy in Couples ...
Makvan Bahramzadeh, MohhamadAli Sepahvandi, Fatemeh Rezaei   +2 more
doaj  

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

A mixed methods study of schema modes amongst people living with eating disorders

Journal of Eating Disorders
Background Schema therapy is promising for people with eating disorders, especially those unresponsive to cognitive behavioural therapy. Complex underlying psychological constructs include dysfunctional schemas and maladaptive modes.
Clare Marney, Marie Reid, Bernice Wright
doaj   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

London SynEx Demonstrator Site: Impact Assessment Report [PDF]

, 2000
The key ingredients of the SynEx-UCL software components are: 1. A comprehensive and federated electronic healthcare record that can be used to reference or to store all of the necessary healthcare information acquired from a diverse range of clinical
Austin, A., Ingram, D., Kalra, D., Lloyd, D., O’Connor, A., Patterson, D.   +5 more
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Effectiveness of Schema Therapy on Modification Early Maladaptive Schemas patient With resistent Obsessive-Compulsion Disorder [PDF]

روانشناسی و روانپزشکی شناخت, 2015
Introduction: Obsessive Compulsive Disorder has been comorbid with several disorder, it accompanies serious problems and deficiencies in the working lives of those afflicted with it. Aim:The purpose of this study was conducted the effectiveness of Schema
Mohammad mehdi Jahangiri, Mahdieh Salehi, Hassan Ashayerih, Hassan pasha Sharifi   +3 more
doaj