Results 81 to 90 of about 2,665,601 (249)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Effectiveness of Schema Therapy and Group Cognitive Therapy on Anxiety in Women with High-Risk Sexual Behavior

Journal of Research Development in Nursing and Midwifery, 2017
                 Effectiveness of Schema Therapy and Group Cognitive Therapy on Anxiety in Women with High-Risk Sexual Behavior Background and Objective: Due to the effectiveness of psychological ...
Akbar Hemmati Sabet, Shokouh Navabi Nejad, Javad Khalatbari   +2 more
doaj   +2 more sources

The Effectiveness of Emotional Schema Therapy on Cognitive Emotion Regulation, Intolerance of Uncertainty and Cognitive Flexibility in People with Generalized Anxiety Disorder [PDF]

Ravānshināsī-i Afrād-i Istis̠nāyī
The aim of this study was to evaluate the effectiveness of emotional schema therapy on cognitive emotion regulation, intolerance of uncertainty and cognitive flexibility in people with generalized anxiety disorder.
Kobra Ghanizadeh Balderloo, Naimeh Moheb, Marziye Alivandi Vafa, Masoumeh Azmoudeh   +3 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

The effectiveness of group schema therapy on early maladaptive schema of traditional and industrial addicts under methadone treatment

مجله علوم روانشناختی, 2019
Background: Much research has pointed to the effectiveness of individualized schema therapy on early maladaptive schemas of traditional and industrial drug users, but there is a research gap in the methadone treatment group in Birjand.
Ali Akbar Nakhee Shamahmood, Ali Arab, Ali Farnam   +2 more
doaj  

Comparing the effectiveness of schema therapy and emotionally focused therapy on couples' marital disaffection

روانشناسی و روانپزشکی شناخت
Introduction: One of the most important problems in the life of couples is marital boredom. It has been proposed to use several educational and therapeutic interventions to improve marital life, among which emotion-oriented therapy and schema therapy can
Elham Mohaddas Pishnamaz, Naser Yosefi, Hasan Mirza Hosseini   +2 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Comparison of the effectiveness of cognitive-behavioral therapy and schema therapy on extramarital relationships and domestic violence in women with emotional divorce

مجله علوم روانشناختی, 2021
Background: Various studies have shown the effectiveness of cognitive-behavioral therapy and schema therapy on behaviors related to emotional divorce in women, but the question is that “are cognitive-behavioral therapy and schema therapy effective on ...
Hossein Kiaee Rad, Reza Pasha, Parviz Asgari, Behnam Makvandi   +3 more
doaj  

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Comparison of the efficacy of acceptance and commitment-based therapy and schema therapy on self-efficacy and craving for change in addicts

مجله علوم روانشناختی, 2021
Background: Studies have shown that low self-efficacy and poor beliefs in abilities in stressful situations are two causes of substance abuse and relapse of addictive behaviors.
Fatemeh Bahram Abadian, Mina Mojtabaie, Mehrdad Sabet   +2 more
doaj