Results 61 to 70 of about 198,870 (287)

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Therapist adherence in cognitive behavioural therapy and schema therapy for depression. [PDF]

, 2019
Maintaining high levels of adherence to therapy modalities is essential to ensure that a therapy is being delivered as prescribed. The current study evaluated therapist adherence to cognitive behavioural therapy (CBT) and schema therapy modalities in the
Rayner, Annalice Lynette
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

CS05-02 - Schema therapy for chronic depression

, 2011
Although schema or schema-focused therapy is now a well-established treatment for personality disorders such as borderline personality disorder, it was originally developed with long-lasting or chronic forms of depression in mind. In this presentation, I
M. Huibers
core   +1 more source

Forensic Schema Therapy: Theoretical Foundations

Психология и право
The article discusses the theoretical model of schema therapy and provides an overview of research on its adaptation for individuals with convictions and those who have committed criminal acts under the influence of a mental illness.
E.D. Surgutskiy, G.A. Vartanyan
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Effects of schema therapy and schema-focused mindfulness therapy on conflict resolution of Iranian women in Malaysia

, 2017
This study aimed to investigate the effectiveness of schema therapy and schema-focused mindfulness therapy on conflict resolution among Iranian married women who lived in Malaysia during ?2015-2016.
Wan Marzuki Wan Jaafar, Wan Jaafar, Wan Marzuki, Nooroney, Nooshin, Mohd Noah, Sidek, Siti Aishah Hassan, Hassan, Siti Aishah, Nooshin Nooroney, Sidek Mohd Noah   +7 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Role and treatment of early maladaptive schemas in Vietnam veterans with PTSD

, 2010
The role of early maladaptive schemas in understanding and treating post-traumatic stress disorder (PTSD) was investigated. The first study examined the role of perceived adverse parenting and early maladaptive schemas in the development of PTSD in ...
Cockram, D.M., Lee, C.W., Drummond, P.D.
core  

The Effectiveness of Emotional Schema Therapy on Neuroticism and the Life Style of Cardiovascular Patients

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2021
BACKGROUND AND OBJECTIVE: Neuroticism and extroversion have a high and positive relationship with psychological problems such as anxiety and depression.
Z Khodadad Hatkeh Poshti, R Hassanzadeh, SO Emadian   +2 more
doaj