Results 61 to 70 of about 2,665,601 (249)
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
The Comparison of the Effectiveness of Emotional Schema Therapy and Mindfulness-Based Cognitive Therapy on Cognitive Emotion Regulation, Intolerance of Uncertainty, and Cognitive Flexibility in Patients with Generalized Anxiety Disorder [PDF]
پژوهشهای کاربردی روانشناختیThe objective was to compare the effectiveness of emotional schema therapy and cognitive therapy based on mindfulness on cognitive regulation of emotion, intolerance of uncertainty, and cognitive flexibility.
Kobra Ghanizadeh Balderloo +3 more
doaj +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
bowtie-json-schema/bowtie: v2023.07.3
, 2023 What's Changed Refactor/transform data once by @harrel56 in https://github.com/bowtie-json-schema/bowtie/pull/311 fix: bug causing error when uploading local report by @AgniveshChaubey in https://github.com/bowtie-json-schema/bowtie/pull/326 Hyperjump -
Julian Berman +9 more
core +1 more source
Forensic Schema Therapy: Theoretical Foundations
Психология и правоThe article discusses the theoretical model of schema therapy and provides an overview of research on its adaptation for individuals with convictions and those who have committed criminal acts under the influence of a mental illness.
E.D. Surgutskiy, G.A. Vartanyan
doaj +1 more source
The Effect of Schema Therapy-Based Group Counseling on Reducing the Psychological Distress Adolescents of Divorce [PDF]
پژوهشهای کاربردی روانشناختیThe purpose of the research was to investigate the effectiveness of schema therapy, which is founded on group counseling, in alleviating the psychological distress experienced by adolescents who have experienced divorce.
Farzaneh Monjezi +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source